1 / 36

Tuberculosis in the United States National Tuberculosis Surveillance System Highlights from 2012

Tuberculosis in the United States National Tuberculosis Surveillance System Highlights from 2012. National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention. Division of Tuberculosis Elimination. Reported TB Cases United States, 1982–2012*. No. of Cases. Year.

neorah
Download Presentation

Tuberculosis in the United States National Tuberculosis Surveillance System Highlights from 2012

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Tuberculosis in the United StatesNational Tuberculosis Surveillance SystemHighlights from 2012 National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention Division of Tuberculosis Elimination

  2. Reported TB Cases United States, 1982–2012* No. of Cases Year *Updated as of June 10, 2013.

  3. TB MorbidityUnited States, 2007–2012 *Cases per 100,000. Updated as of June 10, 2013.

  4. TB Case Rates,* United States, 2012 D.C. <3.2 (2012 national average) >3.2 *Cases per 100,000.

  5. Map of U.S.-Affiliated Pacific Islands by TB Case Rates,* 2012 Northern Mariana Islands • Guam • Marshall Islands • Palau • Federated States of Micronesia • American Samoa ≤9.9 10–49.9 ≥50 *Cases per 100,000

  6. TB Case Rates,* U.S.-Affiliated Pacific Islands, 2012 *Cases per 100,000

  7. TB Case Rates* by Age Group United States, 1993–2012 Cases per 100,000 Age Group (years) * Updated as of June 10, 2013.

  8. Reported TB Cases by Age Group, United States, 2012

  9. TB Case Rates by Age Group and Sex, United States, 2012 Cases per 100,000

  10. TB Case Rates by Race/Ethnicity,* United States, 2003–2012** Cases per 100,000 *All races are non-Hispanic. **Updated as of June 10, 2013.

  11. TB Case Rates by Age Group and Race/Ethnicity,*United States, 2012 Cases per 100,000 *All races are non-Hispanic. Persons reporting two or more races accounted for less than 1% of all cases.

  12. Reported TB Cases by Race/Ethnicity,*United States, 2012 *All races are non-Hispanic. Persons reporting two or more races accounted for less than 1% of all cases.

  13. Number of TB Cases inU.S.-born vs. Foreign-born Persons, United States, 1993–2012* No. of Cases *Updated as of June 10, 2013

  14. Trends in TB Cases in Foreign-born Persons,United States, 1992 – 2012* No. of Cases Percentage *Updated as of June 10, 2013

  15. Reported TB Cases by Origin and Race/Ethnicity,* United States, 2012 Foreign-born** U.S.-born *All races are non-Hispanic. Persons reporting two or more races accounted for less than 1% of all cases. ** American Indian or Alaska Native and Native Hawaiian or Other Pacific Islander accounted for less than 1% of foreign-born cases and are not shown.

  16. Percentage of TB Cases Among Foreign-born Persons, United States* 2002 2012 DC DC >50% 25%–49% *Updated as of June 10, 2013. <25%

  17. TB Case Rates in U.S.-born vs. Foreign-born Persons, United States, 1993 – 2012* Cases per 100,000 *Updated as of June 10, 2013.

  18. TB Case Rates in U.S.-born vs. Foreign-born Persons, United States,* 1993 – 2012** Cases per 100,000 *Includes the same data as slide 15, but rates presented on a logarithmic scale. **Updated as of June 10, 2013.

  19. Countries of Birth of Foreign-born Persons Reported with TB, United States, 2012

  20. Percent of Foreign-born with TB by Time of Residence in U.S. Prior to Diagnosis, 2012 *Foreign-born TB patients for whom information on length of residence in the U.S. prior to diagnosis is unknown or missing

  21. Primary Anti-TB Drug Resistance,United States, 1993 – 2012* % Resistant *Updated as of June 10, 2013. Note: Based on initial isolates from persons with no prior history of TB. Multidrug resistant TB (MDR TB) is defined as resistance to at least isoniazid and rifampin

  22. Primary MDR TB,United States, 1993 – 2012* No. of Cases Percentage *Updated as of June 10, 2013. Note: Based on initial isolates from persons with no prior history of TB. MDR TB defined as resistance to at least isoniazid and rifampin.

  23. Primary Isoniazid Resistance in U.S.-born vs. Foreign-born Persons,United States, 1993 – 2012* % Resistant *Updated as of June 10, 2013. Note: Based on initial isolates from persons with no prior history of TB.

  24. Primary MDR TB in U.S.-born vs. Foreign-born PersonsUnited States, 1993 – 2012* % Resistant *Updated as of June 10, 2013. Note: Based on initial isolates from persons with no prior history of TB. MDR TB defined as resistance to at least isoniazid and rifampin.

  25. XDR TB Case Count Defined on Initial DST*by Year, 1993 – 2012** Case Count Year of Diagnosis * Drug susceptibility test ** Updated as of June 10, 2013. Note: Extensively drug-resistant TB (XDR TB) is defined as resistance to isoniazid and rifampin, plus resistance to any fluoroquinolone and at least one of three injectable second-line anti-TB drugs

  26. Reporting of HIV Test Results in Persons with TB by Age Group,United States, 1993 – 2012* % with Test Results *Updated as of June 10, 2013. Note: Includes persons with positive, negative, or indeterminate HIV test results and persons from California with co-diagnosis of TB and AIDS. Rhode Island did not report HIV test results for years 1993–1997. HIV test results for Vermont are not included for years 2007–2010. HIV test results for California are not included for years 2005 - 2010

  27. Estimated HIV Coinfection in Persons Reported with TB, United States, 1993 – 2012* % Coinfection *Updated as of June 10, 2013 Note: Minimum estimates based on reported HIV-positive status among all TB cases in the age group

  28. TB Cases by Residence in Correctional Facilities, Age ≥15, United States, 1993-2012* *Updated as of June 10, 2013 Note: Resident of correctional facility at time of TB diagnosis

  29. TB Cases Reported as Homeless in the 12 Months Prior to Diagnosis, Age ≥15, United States, 1993-2012* *Updated as of June 10, 2013 Note: Homeless within past 12 months of TB diagnosis

  30. Mode of Treatment Administration in Persons Reported with TB,United States, 1993 – 2010* Percentage** *Updated as of June 10, 2013. Data available through 2010 only. **Percentage of total cases in persons alive at diagnosis, with an initial regimen of one or more drugs prescribed, and excluding cases with unknown mode of treatment administration. Directly observed therapy (DOT); Self-administered therapy (SA)

  31. Completion of TB Therapy,United States, 1993 – 2010* Percentage * Updated as of June 10, 2013. Data available through 2010 only. Note: Includes persons alive at diagnosis, with initial drug regimen of one or more drugs prescribed, who did not die during therapy. Excludes persons with initial isolate rifampin resistant, or patient with meningeal disease, or pediatric patient (aged <15) with miliary disease or positive blood culture.

  32. Definition for Tuberculosis Genotypingin the United States Spoligotype: 000000000003771 Initial 12-locus MIRU-VNTR1: 223325173533 Additional 12-locus MIRU-VNTR (MIRU2): 4445344234282 Sequentially assigned for each unique spoligotype and initial 12-locus MIRU-VNTR combination PCRType:PCR00002 + GENType: G00010 Sequentially assigned for each unique spoligotype and 24-locus MIRU-VNTR combination 1 Mycobacterial interspersed repetitive unit–variable number tandem repeat 2 The complete set of 24 loci is referred to as 24-locus MIRU-VNTR and is used for GENType designation for genotype in the U.S.

  33. National Tuberculosis Genotyping Surveillance Coverage* by Year, United States, 2004–2012 Proportion of culture confirmed TB cases genotyped (%) National Indicator 94% * The proportion of positive cultures with at least one genotyped isolate

  34. Number and Percent of Unique* andCounty-GENType Clustered** Cases,United States, 2010–2012 *Unique case is a case with a spoligotype and 24-locus locus MIRU-VNTR (GENType) that does not match any other case in that county during the specified 3-year time period ** Two or more cases with matching spoligotype and 24-locus locus MIRU-VNTR (GENType) within a county during the specified 3-year time period

  35. Number of County-based Tuberculosis Genotype Clusters* by Cluster Size, United States, 2010–2012 Number of Cases in a Cluster *Genotype cluster is defined as two or more cases with matching spoligotype and 24-locus MIRU-VNTR (GENType) within a county during the specified 3-year time period

  36. Tuberculosis Genotype Clusters by TB GIMS*Alert Levels**,United States, 2010-2012 *Tuberculosis Genotyping Information Management System **Alert level is determined by the log likelihood ratio statistic (LLR) for a given cluster, identifying higher than expected geospatial concentrations for a TB genotype cluster in a specific county, compared to the national distribution of that genotype; TB GIMS generates alert level notifications based on this statistic: “No alert” is indicated if LLR is between 0–5, “medium” is for LLR of 5.1–10 and “high” alert is for clusters with LLR >10

More Related