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PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol

5. (A). *. *. 4. *. *. *. *. *. 3. *. Response Latency (s). *. *. PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol. 2. 1. 0. 15. 30. 45. -10. Time (min). 5. (B). 4. PBS 10 mg/kg caffeine

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PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol

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  1. 5 (A) * * 4 * * * * * 3 * Response Latency (s) * * PBS 10 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol 2 1 0 15 30 45 -10 Time (min) 5 (B) 4 PBS 10 mg/kg caffeine 10 mg/kg paracetamol + 10 mg/kg caffeine 50 mg/kg paracetamol + 10 mg/kg caffeine 100 mg/kg paracetamol + 10 mg/kg caffeine 200 mg/kg paracetamol + 10 mg/kg caffeine 3 Response Latency (s) 2 * * 1 0 45 -10 15 30 Time (min) (C) 4 5 3 # PBS Paracetamol 10 mg/kg caffeine Paracetamol + 10 mg/kg caffeine 2 Response Latency (s) # # * 1 0 0 1000 10 100 Dose of paracetamol (mg/kg)

  2. 5 (A) 4.5 4 * 3.5 * * 3 * Response latency (sec) 2.5 2 1.5 1 0.5 0 -10 15 30 45 time (min) 5 (B) 4.5 4 * PBS 50mg/kg paracetamol 10mg/kg PSB1115 50mg/kg paracetamol + 10mg/kg PSB1115 3.5 3 Response latency (sec) 2.5 2 1.5 1 0.5 0 -10 15 30 45 time (min) PBS 50mg/kg paracetamol 3mg/kg SCH58261 50mg/kg paracetamol + 3mg/kg SCH58261

  3. 20 (A) * * 15 * * * * * * PBS 10 mg/kg paracetamol 20 mg/kg paracetamol 50 mg/kg paracetamol 100 mg/kg paracetamol 200 mg/kg paracetamol * Response Latency (s) * * * 10 5 0 -10 15 30 45 Time (min) 20 (B) * * 15 * PBS 10 mg/kg caffeine 50 mg/kg paracetamol + 10 mg/kg caffeine 100 mg/kg paracetamol + 10 mg/kg caffeine 200 mg/kg paracetamol + 10 mg/kg caffeine * * * * 10 Response Latency (s) 5 0 -10 15 30 45 Time (min) 20 (C) 15 PBS Paracetamol 10 mg/kg caffeine Paracetamol + 10 mg/kg caffeine # 10 Response Latency (s) 5 0 0 10 100 1000 Dose of paracetamol (mg/kg)

  4. 20 (A) PBS 50mg/kg paracetamol 3mg/kg SCH58261 50mg/kg paracetamol + 3mg/kg SCH58261 15 * * * Response Latency (sec) * * * * 10 5 0 -10 15 30 45 20 time (min) (B) # 15 * * PBS 50mg/kg paracetamol 10mg/kg PSB1115 50mg/kg paracetamol + 10mg/kg PSB1115 * Response Latency (sec) * * * 10 5 0 -10 15 30 45 time (min)

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