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Particle Inlet

Development of an analyzer for size and charge characterization of nano-particles for research and education Malay K. Mazumder, University of Arkansas at Little Rock, DMR 0526977 Intrinsic Merit.

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Particle Inlet

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  1. Development of an analyzer for size and charge characterization of nano-particles for research and education Malay K. Mazumder, University of Arkansas at Little Rock, DMR 0526977Intrinsic Merit A laser based instrument to measure simultaneously both particle size and electrostatic charge distributions in real time and on a single particle basis for particles in the size range 50 to 5000 nm in diameter is being developed. The instrument employs a laser Doppler Velocimeter (LDV) probe that analyzes the response of particle motion under the excitation of ac electric and acoustic fields. The diameter (da) and the charge (q) of each particles passing through the LDV sensing volume, are determined by measuring the phase lag and the amplitude ratio of the oscillatory particle motion with respect to the applied sinusoidal fields. Particle Inlet PMT DSP Scattered light Laser beams AC electrode AC electrode ESPART Block diagram Mini LDV components

  2. Development of an analyzer for size and charge characterization of nano-particles for research and education Malay K. Mazumder, University of Arkansas at Little Rock, DMR 0526977Broader Impacts Humidity Controlled Chamber Vacuum Gage DPI To Vacuum Air Valves Grounded Aerosol Holding Chamber ESPART Respiratory drug delivery of fine dry powder aerosol for treating lung diseases like asthma, cystic fibrosis, and emphysema is an inefficient process due to two major problems: (1) inefficient dispersion of powders, particularly when breath-actuated from the dry powder inhalers (DPI), and (2) loss of particles in the throat and in the upper airways of the lung. Only 15% of the fine particles can reach the lower respiratory regions. The remaining 85% of the aerosolized drug is wasted, ending up as a systemic burden to the body. Precision control of size and charge of the particles is needed for improving efficiency of both dispersion and delivery. Other applications are: electrostatic coating, electrospray, electrostatic self-assembly of nanoparticles and high resolution electrophotography. A California based company has expressed an interest in manufacturing the analyzer and a New York based company has expressed interest in marketing it in the US and abroad. Particle Size and Electrostatic Charge measurement of Inhaler Aerosols using ESPART Analyzer Relative Charge Distribution of Three DPI Aerosols

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