1 / 11

CDC Smallpox Vaccine Production

CDC Smallpox Vaccine Production . ACIP May 8, 2002 . Smallpox Vaccine Products. Overview . Wyeth Dryvax (1:1 & 1:5) Acambis Vaccinia Vaccine in MRC5 Cells (Acam1000) Acambis Vaccinia Vaccine in Vero Cells (Acam2000) Aventis Pasteur Vaccine. ~54 million doses . Acam 1000.

ostinmannual
Download Presentation

CDC Smallpox Vaccine Production

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. CDC Smallpox Vaccine Production ACIP May 8, 2002

  2. Smallpox Vaccine Products Overview • Wyeth Dryvax (1:1 & 1:5) • Acambis Vaccinia Vaccine in MRC5 Cells (Acam1000) • Acambis Vaccinia Vaccine in Vero Cells (Acam2000) • Aventis Pasteur Vaccine

  3. ~54 million doses Acam 1000 ~155 million doses Acam 2000 Dryvax AvP Vaccine 15 million doses – undiluted 75 million @ 1:5 dilution 70-90 million doses Smallpox Vaccine Supply and Production 2001 2002 2003 2004 2005 1983

  4. Smallpox Vaccine Related Supplies Overview Provides for: • Bifurcated Needles • 15 million for original Dryvax stock • 60 million for 1:5 dilution Dryvax supplies • Diluent for 1:5 Dryvax • Protocols • Storage & Distribution • VIG

  5. ACAM2000 Development

  6. Passage History

  7. ACAM2000 Manufacturing Overview

  8. Acam 1000/2000 Stockpile

  9. Acam 1000 Human Clinical Trial

  10. group group # of subjects # of subjects vaccination vaccination completion completion 1 20 5-Mar-02 19-Apr-02 2 16 13-Mar-02 27-Apr-02 3 24 26-Mar-02 10-May-02 Acam1000 Phase I Clinical Trial

  11. SMALLPOX VACCINE PRODUCTION Summary • Vaccine for “All Americans” by end of 2002 • All vaccines now under IND • Clinical trials through Phase 2 done by end of 2002; licensure late 2003 or 2004 • Production includes bifurcated needles, dil. • VIG contract under negotiations now • NPS storage site for rapid deployment

More Related