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Ryan Simpson Adrian Smalley Jenessa Dilley

Hair as a Biological Indicator of Drug Use, Drug Abuse and Chronic Exposure to Environmental Toxins. Ryan Simpson Adrian Smalley Jenessa Dilley. Advantages. Larger detection windows From 3 days to years Depending on the length of the hair shaft Evaluation of long to short term history

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Ryan Simpson Adrian Smalley Jenessa Dilley

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  1. Hair as a Biological Indicator of Drug Use, Drug Abuse and Chronic Exposure to Environmental Toxins Ryan Simpson Adrian Smalley Jenessa Dilley

  2. Advantages • Larger detection windows • From 3 days to years • Depending on the length of the hair shaft • Evaluation of long to short term history • Discriminative • Active and passive exposure • Non-invasive sample collection • Broader Applications

  3. Anatomy of Hair

  4. Hair Growth Stages • Telogen • Return to Anagen Anagen Catagen

  5. Incorporation Into Hair • Capillary surrounding follicle • Provides Nutrients • Extraneous Substances • Other levels of incorporation • Tissues • Lymph • Intracellular Fluids

  6. Detectable Substances Opiates Cocaine Amphetamines Cannabinoids Prescription Drugs Nicotine Antidepressants Antipsychotics

  7. Detectable Habits Chronic Alcohol Consumption Drug Addiction

  8. Environmental Toxins Pollution Pesticides Neonatal Exposure Work Hazards

  9. Sample Collection & Preparation • Collection • Vertex • Less variability in growth • Less subject to age and sex related influence • Growth phases are more consistent • Washing • Removes external contaminants • Extractions • Alkaline Digestion • Acidic Digestion • Enzymatic Digestion

  10. Hair Analysis • Analytical Requirements • Sensitivity • Specificity • Absence of Matrix Effects • Immunoassays • HPLC & CE • GC-MS & GC-MS/MS • Infrared Microscopy

  11. Applications • Doping Controls • Drug Abuse Studies • Drug History • Type and Extent • Forensic Toxicology • Acute Drug Poisoning

  12. Applications • Evaluate Environmental Exposure to Toxicants • Clinical Chemistry • Compliance of Patience to Doctor’s Prescription • Clinical Toxicology • Prenatal Exposure Assessment • Diagnostic Biomarkers

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