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CRITICAL PERIOD. Modified from MacLusky and Naftolin Science 1981; 211:1294 - 1303. OH. Testosterone. O. Aromatase. 5 a - Reductase. OH. HO. O. Estradiol. 5 a - DHT. Androgen-dependent sexual dimorphism in the CNS. Ultrastructural differences Neuronal nuclear and nucleolar size
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CRITICAL PERIOD Modified from MacLusky and Naftolin Science 1981; 211:1294 - 1303
OH Testosterone O Aromatase 5a - Reductase OH HO O Estradiol 5a - DHT
Androgen-dependent sexual dimorphism in the CNS • Ultrastructural differences • Neuronal nuclear and nucleolar size • Differences in synaptic or dendritic organization • Differences in the gross volume of defined cell groups
CELL MIGRATION A B Arnold and Gorski 1984
10 20 30 12 36 60 Age (weeks) Time (hr)