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Steering Committee Meeting

Steering Committee Meeting. Quality Control Committee Report February 8 th , 2007. Overview. Exam 4 Quality Control Surveillance Additional Investigations. Exam 4 QC Committee Surveillance. Clinic Anthropometry measures (intra- and inter-technician)

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Steering Committee Meeting

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  1. Steering Committee Meeting Quality Control Committee Report February 8th, 2007

  2. Overview • Exam 4 Quality Control Surveillance • Additional Investigations

  3. Exam 4 QC Committee Surveillance • Clinic • Anthropometry measures (intra- and inter-technician) • Form data mean, variance, outliers (BP and anthro) • Interviewer protocol adherence • CT • Blind rereads (intra- and inter-reader) • Torso phantom monitoring • Protocol Violations • Laboratory • Blind duplicate assays (group 1) • Ancillary Studies (Family, Lung, MRI, …)

  4. Additional Investigations • Drift in Fasting Glucose • Drift in Urinary Creatinine and Albumin • MESA Family Ultrasound comparability • EBCT and 64 Slice MDCT comparability • Cardiac MRI Field Center differences

  5. Fasting Glucose Drift • Tracy Investigative Subcommittee formed 9/07 • Recommendation to sample 800 specimens • 200 from each of the 4 exams • stratified by Exam quarter (50 each) • and stratified by glucose quintile (10 each). • Assay results transmitted to CC last week. • Report initiated and scheduled for release to Tracy Investigative Committee on 2/13/07.

  6. MRI Center Differences Linear regression Number of obs = 5000 F( 15, 4984) = 446.81 Prob > F = 0.0000 R-squared = 0.5964 Root MSE = 25.141 ------------------------------------------------------------------------------ | Robust olvedm1 | Coef. Std. Err. t P>|t| [95% Conf. Interval] -------------­+---------------------------------------------------------------- 4: COL | 12.72629 1.423397 8.94 0.000 9.935803 15.51677 5: JHU | 2.613263 1.378837 1.90 0.058 -.0898654 5.316391 6: UMN | 18.06299 1.380556 13.08 0.000 15.35649 20.76949 7: NWU | 9.425192 1.291795 7.30 0.000 6.892705 11.95768 8: UCLA | 5.455308 1.496009 3.65 0.000 2.522471 8.388145 age1c | -.3233225 .0470374 -6.87 0.000 -.4155365 -.2311085 wtlb1 | .3754949 .0142763 26.30 0.000 .3475071 .4034827 htcm1 | .6318455 .0641437 9.85 0.000 .5060957 .7575953 gender1 | 29.12208 1.170361 24.88 0.000 26.82766 31.41651 race1c_2 | -1.979374 1.342958 -1.47 0.141 -4.612163 .653415 race1c_3 | 8.72663 1.040092 8.39 0.000 6.687593 10.76567 race1c_4 | 2.444399 1.221481 2.00 0.045 .049759 4.83904 sbp1c | .4466735 .0299493 14.91 0.000 .3879597 .5053874 dbp1c | -.1421031 .0598686 -2.37 0.018 -.259472 -.0247343 htnmed1c | 5.490219 .8400984 6.54 0.000 3.843256 7.137181 _cons | -75.88663 11.03512 -6.88 0.000 -97.52033 -54.25293 ------------------------------------------------------------------------------

  7. MRI Center Differences • After adjustment for common risk factors, there appears to be a significant Field Center effect on End Diastolic Mass (on average UMN LV Mass measures are 18 grams more than WFU, JHU LVMass is 2.6 grams more than WFU …). • Pairwise differences between all Field Centers are believed to be statistically significant. • Regressions of LV Mass Index (weight and height adjusted variant) produce similar results. • Effects also apparent for: • End Diastolic Volume • End Systolic Volume • Stroke Volume • Ejection Fraction • Cardiac Output

  8. Routine Investigation • No evidence for • Time trends • Image quality effect • Protocol adherence effect • Technician effect • Manufacturer effect (GE vs Siemens)

  9. CT LV Size Adjustment Linear regression Number of obs = 5000 F( 16, 4983) = 657.68 Prob > F = 0.0000 R-squared = 0.7310 Root MSE = 20.525 ------------------------------------------------------------------------------ | Robust olvedm1 | Coef. Std. Err. t P>|t| [95% Conf. Interval] -------------+---------------------------------------------------------------- 4: COL | -1.062079 1.160226 -0.92 0.360 -3.336633 1.212476 5: JHU | -1.25548 1.096965 -1.14 0.252 -3.406015 .8950548 6: UMN | 16.16367 1.127796 14.33 0.000 13.95269 18.37464 7: NWU | -.8253703 1.068237 -0.77 0.440 -2.919586 1.268845 8: UCLA | -4.030186 1.154943 -3.49 0.000 -6.294381 -1.76599 age1c | .1871892 .0397874 4.70 0.000 .1091883 .2651901 wtlb1 | .2996125 .0120323 24.90 0.000 .2760238 .3232011 htcm1 | -.1952002 .058762 -3.32 0.001 -.3103996 -.0800009 gender1 | 19.25727 .8976507 21.45 0.000 17.49748 21.01706 _Irace1c_2 | -1.119526 1.093914 -1.02 0.306 -3.264079 1.025027 _Irace1c_3 | 4.665182 .831245 5.61 0.000 3.035576 6.294788 _Irace1c_4 | 1.596157 .9849146 1.62 0.105 -.3347087 3.527024 sbp1c | .1749503 .0240008 7.29 0.000 .1278981 .2220025 dbp1c | .1621186 .047622 3.40 0.001 .0687586 .2554786 htnmed1c | 3.787789 .6741172 5.62 0.000 2.466222 5.109355 lvs | .3632597 .0105439 34.45 0.000 .342589 .3839304 _cons | .4006381 9.054353 0.04 0.965 -17.34988 18.15116 ------------------------------------------------------------------------------

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