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Regenerative Medicine

Regenerative Medicine. Anita Mol, Carlijn Bouten, Simon Hoerstrup, Frank Baaijens Laboratory for Tissue Biomechanics and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology. Healthcare-transforming technologies.

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Regenerative Medicine

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  1. Regenerative Medicine Anita Mol, Carlijn Bouten, Simon Hoerstrup, Frank Baaijens Laboratory for Tissue Biomechanics and Tissue Engineering, Department of Biomedical Engineering, Eindhoven University of Technology

  2. Healthcare-transforming technologies Minimally Invasive surgeryReducing patient trauma and reduces costs ImagingEarlier diagnosis saves lives and reduces costs Clinical ITRight Information at the right time enables best treatment and reduces costs Molecular MedicinePreventing disease from happening and reduces costs Regenerative medicineImplants taking over vital bodily functions, improving quality of life Adapted from: Russ Coile, Futurescan 2003, SG-2

  3. Heart valves

  4. Valve replacements 300.000 replacements / year Main drawback: no growth, repair and adaptation

  5. Tissue formation, matrix remodelling Implantation/ Model system (Mechanical) preconditioning Cells Scaffold Isolation of cells from vessels Seeding in scaffold Culture, conditioning Tissue formation Implantation vsmc endothelial cells Tissue Engineering Paradigm

  6. Proof-of-concept: sheep cells Hoerstrup et al. Circulation 2000 Implanted as pulmonary heart valve replacement 6 weeks 16 weeks 20 weeks Not sufficient load-bearing properties to serve as aortic valve replacement

  7. Challenge • Develop a living, autologous valve replacement, able to grow, repair and adapt to changing environment using human cells • Sufficiently strong for aortic (high pressure) side

  8. Strong, functional human valves! Mol et al. Circulation 2006 Effective orifice area: 1.52  0.21 cm2 Mean systolic gradient: 11.5  3.1 mm Hg Regurgitation: 18.2  4.2 % Dynamically conditioned tissue engineered human heart valve

  9. Discussion Tissue engineered human heart valves show promising features as aortic valve replacements • Functional parameters are in the range of those reported for commonly used bioprostheses • Upcoming animal studies will elucidate short- and long-term functionality of tissue-engineered heart valves in aortic position and the capability of growth and remodeling

  10. Engineered tissues (In-vitro)

  11. Eindhoven, BMT, TBME Dr. Anita Mol Drs. Marjolein van Lieshout Ir. Niels Driessen Ir. Ralf Boerboom Ir. Angelique Balguid Ir. Rolf Pullens Ir. Martijn Cox Ir. Mirjam Rubbens Christa Dam Katy Krahn Dr. Carlijn Bouten Dr. Marcel Rutten Dr. Claudia Vaz Dr. Gerrit Peeters Prof. Bas de Mol Prof. Frank Baaijens Eindhoven, BMT / ST, SMO Ir. Eva Wisse Drs. Patricia Dankers Dr. Nico Sommerdijk Dr. Maarten Merkx Prof. Bert Meijer Eindhoven, BMT, BEMI Prof. Klaas Nicolaij Dr. Gustav Strijkers Zürich Dr. Stephan Neuenschwander Dörthe Schmidt, MSc. Prof. Simon Hoerstrup Leiden, TNO TPG Dr. Ruud Bank Rotterdam, Dutch Heart Valve Bank Dr. J. van Kats, prof. A. Bogers Grants Bio-Initiative, Eindhoven University of Technology Vici grant, Netherlands Organisation for Scientific Research BioPolymers program, Dutch Polymer Institute Acknowledgements

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