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Pregabalin Efficacy in Peripheral Neuropathic Pain

Pregabalin Efficacy in Peripheral Neuropathic Pain. Results from the first 15 months of an ongoing open-label study in patients with treatment-refractory pain: Peripheral neuropathic pain analysis. Refractory Pain Study – Peripheral Neuropathic Pain Analysis: Inclusion Criteria.

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Pregabalin Efficacy in Peripheral Neuropathic Pain

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  1. Pregabalin Efficacy in Peripheral Neuropathic Pain Results from the first 15 months of an ongoing open-label study in patients with treatment-refractory pain: Peripheral neuropathic pain analysis.

  2. Refractory Pain Study – Peripheral Neuropathic Pain Analysis: Inclusion Criteria • Patients with DPN or PHN who had previously taken part in placebo-controlled, double-blind pregabalin trials • Refractory to: • Gabapentin ≥1800 mg/day AND • Tricyclic antidepressant ≥75 mg/day AND • ≥1 3rd line agent (e.g. AED, narcotic, SSNRI, NSAID) • Refractoriness defined as inadequate pain relief for 2 weeks and/or intolerable side-effects on each of the above • SF-MPQ pain VAS score ≥40 mm • Allowed to continue all pain medications • No inferential testing performed Adapted from D'Urso De Cruz et al. Diabetes 2005; 54 (Suppl. 1): A139 (abstract).

  3. Refractory Pain Study – Peripheral Neuropathic Pain Analysis: Design Overview Relapse Relapse Relapse Relapse “How much has your pain worsened since discontinuing study medication?” Treatment period = 3-month open-label treatment period with pregabalin 150-600 mg/day Drug holiday = pregabalin drug holiday. Only 4 patients did not relapse during drug holidays. Relapse Adapted from D'Urso De Cruz et al. Diabetes 2005; 54 (Suppl. 1): A139 (abstract).

  4. Refractory Pain Study – Pain Reported on Pregabalin Treatment* and During Drug Holidays DH = pregabalin drug holiday. Only 4 patients did not relapse during drug holidays. *15-month open-label pregabalin treatment analysis Adapted from D'Urso De Cruz et al. Diabetes 2005; 54 (Suppl. 1): A139 (abstract).

  5. Refractory Pain Study – Peripheral Neuropathic Pain Analysis: Distribution of Pain Severity at Baseline and 15 Months No/Mild Pain: 0-39; Moderate Pain: 40-69; Severe Pain: ≥70 on SF-MPQ pain VAS 15-month analysis (LOCF). Only 4 patients did NOT relapse during drug holidays. Adapted from D'Urso De Cruz et al. Diabetes 2005; 54 (Suppl. 1): A139 (abstract).

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