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THIS LECTURE COVERS

THIS LECTURE COVERS. Background Level of Response (LR) ALSPAC Data at Age 12 Outcomes. THIS LECTURE COVERS. Background Level of Response (LR) ALSPAC Data at Age 12 Outcomes. ALCOHOLISM RISK. Multiple Characteristics and Genes. GENETIC RISK FACTORS. Level of Response (LR)

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THIS LECTURE COVERS

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  1. THIS LECTURE COVERS • Background • Level of Response (LR) • ALSPAC Data at Age 12 • Outcomes

  2. THIS LECTURE COVERS • Background • Level of Response (LR) • ALSPACData at Age 12 • Outcomes

  3. ALCOHOLISM RISK Multiple Characteristics and Genes

  4. GENETIC RISK FACTORS • Level of Response (LR) • Impulsivity • Psychiatric Disorders • Alcohol Metabolizing Enzymes

  5. LR RATIONALE • Youth Drink for Effects • If Need more, Will Drink More • Then Heavy Drinking Affects Peers Expectations Stress

  6. SRE TIME FRAME:DRINKS 1st 5 Recent Heaviest NEEDED TO: Times 3 Mo. Feel Effect Feel Dizzy or Slur Speech Stumble Fall Asleep

  7.  San Diego Study  Australian Twins  Danish Adoptees  Colorado Twins COGA Kids ALSPAC Kids Pittsburgh Study LR PREDICTS OUTCOME

  8. THIS LECTURE COVERS • Background • Level of Response (LR) • ALSPAC Data at Age 12 • Outcomes

  9. BEFORE ALSPAC • Subjects Age 18+ • Not General Population • Most From U.S.

  10. ALSPAC DRINKERS AT 12 Age 12Age 14 Age 12.4 13.9 Drinks/Week 2.6 3.4a Max Drinks 4.2 5.1c % Problems 29 42a

  11. REGRESSIONS AT 12

  12. THIS LECTURE COVERS • Background • Level of Response (LR) • ALSPACData at Age 12 • Outcomes

  13. ALSPAC DRINKERS 12/14 Age 12Age 14 Age 12.4 13.9 Drinks/Week 2.6 3.4a Max Drinks 4.2 5.1c % Problems 29 42a

  14. PEER EXPECT LR ALCOUT FHalc COPE PROJECTED

  15. PROSPECTIVE CORRELATION a p<.05, b p<.001

  16. SEX .09 .08 AGE ALCOUT .19 PEER LR .28 .25 .37

  17. 1,905 CROSS SECTIONAL Boys = 44% Age = 17.8 Alcohol Freq = 5 D/mo Q Usual = 4.6 Drinks Q Max = 13.4 Drinks Problems = 49.5%

  18. 1,905 ALSPAC 17-YEAR-OLDS

  19. AGE .07 .12 COPE ALCOUT EXPECT PEER LR .24 .59 .05 GENDER

  20. FUTURE DIRECTIONS Prospective With Full Sample Follow-up Later Onset Kids Prevention Trial

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