The Center for Children’s Cancer Research

1. The Center for Children’s Cancer Research Welcome and Introduction: June 11, 2010

2. Agenda for today Introduction to, and overview of C3R Email sign-up sheet Break out into C3R Subgroups

3. Cancer Center Structure Multiple buildings, departments, schools, etc. Shared Resources: DNA Peptide Flow Cytometry Biomolecular NMR Tissue Resource and Applications Microarray and Genomic Analysis Research Informatics Genetic Counseling Survey Methods and Data Collection Biostatistics Clinical Trials Office $ $ NCI: CCSG HCI $ $ $ $ $ Nuclear Control of Cell Growth and Differentiation Cell Response and Regulation Imaging, diagnostics, and therapeutics Cancer Control and Population Sciences programs Gastrointestinal Cancers Program

4. What is the point of a “program”? • Organizational structure to facilitate interactions around a topic • Could be scientific topic • Could be clinical topic • Help to achieve cancer center goals • Cancer focus • Collaboration (synergy) • Translational research • Clinical research • Financial support • Program funds can be used in a variety of ways, based on program goals • Support pilot projects • Develop infrastructure • Stimulate collaboration (PPGs, SPORES) • Stimulate translational research • Special symposium, invite speakers, hold meetings

5. How is success of a program measured? • Cancer Focus • What do investigators work on? • What do their grants and papers suggest they work on? • Scientific quality • Number of papers • Quality/impact of papers • Funding • NCI funding is most important • overall amount is also important • Synergy • Collaborative papers • Collaborative grants • Collaboration can be either “intra-programmatic” or “inter-programmatic” • Both are important • Impact on patients • Translational work • Clinical trials and enrollment • Use of resources • The CCSG “likes” to see use of core facilities and cancer center resources

6. New Disease-Centric Programs? Nuclear Control of Cell Growth and Differentiation Cell Response and Regulation Imaging, diagnostics, and therapeutics Cancer Control and Population Sciences current programs Gastrointestinal Cancers Program Pediatric Cancers Program (C3R) Breast Cancer Cutaneous Oncology

7. A disclaimer: does C3R really want or need to be a program? • Theoretical pros: • Financial support • Participation in cancer center functions • Core access • Theoretical cons: • Higher level of scrutiny (grants, papers, etc.) • Need to compete during CCSG renewal • More documentation requirements • “Gutting” of other programs

8. What do we need to develop a pediatric cancers “program”? • Members • Spanning basic, translational, clinical, and population sciences • Overarching theme(s) • Won’t be able to do everything • Plan for transdisciplinary collaborative research • Papers • Grants • Translational research • Clinical trials • How best to include folks with significant clinical responsibilities? • Plan for self-sufficient funding • Core infrastructure

9. Center for Children’s Cancer Research • Collaboration between HCI and Pediatrics • Umbrella to organize pediatric cancer research on-campus • Possible precursor to Cancer Center Program

10. C3R Mission Statement To improve the care of children, adolescents, and young adults with cancer through transdisciplinary research

11. C3R Organizational Structure Steering Committee: Steve Lessnick Lor Randall Josh Schiffman Phil Barnette Dan Fults Soumen Khatua “C3R Supergroup” Solid Tumor Liquid Tumor Infrastructural support (cores, support personnel, etc.) Brain Tumor

12. Subgroup Organization Brain Tumor (Dan Fults, Soumen Khatua) Solid Tumor (Steve Lessnick, Lor Randall) Liquid Tumor (Josh Schiffman, Phil Barnette) Separate monthly working meetings

13. Monthly plan (for now) • 1st Friday: Steering committee meeting • 2nd Friday: Supergroup meeting • 3rd week (day TBD): Subgroup meeting • 4th week: TBD • are there other standing meetings that would be helpful? • e.g., clinical trial development, junior investigator, translational research, etc.?

14. New Infrastructure:Comparative Oncology Resource (COR) • COR is a developing Cancer Center core • Provides animal model and preclinical testing expertise • New hire: RupengZhuo, PhD • C3R “liaison” to the COR • Available to C3R members for preclinical studies

15. What other shared resources needed?

16. Advisory Board(s) • External Advisory Board • Stuart Orkin (DFCI/Harvard—leukemia, sarcoma, animal models) • David Malkin (Sick Kids, Toronto—genetic syndromes, sarcoma) • Lee Helman (NCI—sarcoma, early phase clinical trials) • Internal Advisory Board • David Jones (HCI Senior Leadership oversight, including financial management) • Carrie Byington (clinical investigation) • Alana Welm (animal models and preclinical studies)

17. Summer/Fall Plan Standing meetings through the summer Advisory Board meeting September HCI and Pediatric senior leadership meeting following advisory board meeting

18. Opportunities/challenges Lots of interested individuals on-campus Some collaborative projects already HCI and Pediatric support Relatively low NIH/NCI funding overall Widely dispersed “membership” Real and perceived barriers between hospitals and healthcare systems

19. Where do we go from here? • Sign up sheet—indicate which subgroup, too • Arrange portal and distribution lists • Attend supergroup (and subgroup?) meetings • Identify collaborative opportunities • Particularly interested in finding interactions that will impact on patient care, eventually • Start thinking about collaborative grants and papers

20. Learn the C3R “4 questions” Is there a Cancer Focused opportunity? Is there a Collaborative opportunity? Is there a Translational opportunity? Is there a Clinical Trial opportunity? Stay focused on the mission! Participate!!!