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John Kanellopoulos, MD Clinical Associate Professor NYU Medical School, NY

Long term comparison of sequential to combined collagen cross-linking (CXL) and limited topography-guided PRK ( tPRK ) for keratoconus (KCN ) World Cornea Congress Boston 2010. John Kanellopoulos, MD Clinical Associate Professor NYU Medical School, NY

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John Kanellopoulos, MD Clinical Associate Professor NYU Medical School, NY

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  1. Long term comparison of sequential to combined collagen cross-linking (CXL) and limited topography-guided PRK (tPRK) for keratoconus (KCN )World Cornea Congress Boston 2010 John Kanellopoulos, MD Clinical Associate Professor NYU Medical School, NY Director, Laservision.gr Institute, Athens, Greece Financial interest: travel expense reimbursement from Wavelight (in the past) www.brilliantvision.com

  2. We introduced utilizing a partial topography-guided PRK normalization in progressive keratoconic corneas previously stabilized by CXL.(Kanellopoulos AJ & Binder P: J Cornea July 2007) The topography story line below shows; A; pre-op, B: post CXL, C: difference A-B, D: the topo-guided treatment plan with the Wavelight platform, E: the conrea a year later, F: the difference B-E. G and H show the other untreated eye www.brilliantvision.com

  3. Our combined technique employs the partial PRK first, then riboflavin drops and CXL immediately after: www.brilliantvision.com

  4. Methods new technique: 1-Topo-customised surface ablation Epithelial removal: 6.5mm 50nm PTK Custom topography-guided treatment utilizing Wavelight topo-guided software (topo or oculink) (75% cylinder, some or all sphere limited by cornea thickness up to 50 microns, OZ at least 5mm) MMC 0.02% for 30 sec • 2-Then UVA CCL 3mW/cm2 for 30 minutes with riboflavin 0.1% drops • Follow-up 18-36 months www.brilliantvision.com

  5. Study design 325 KCN cases were evaluated for UCVA, BSCVA, refraction, keratometry (K), topography, endothelium and clarity. 115 eyes (group A) had tPRK at least 6 months following CCL, 200 eyes (group B) had first tPRK combined with CCL. Mean follow-up was 26 months. www.brilliantvision.com

  6. Results • Group A (had tPRK at least 6 months following CXL): The mean improvement of UCVA was 0.12 to 0.41, BSCVA 0.42 to 0.68. • Group B (had first tPRK combined with CXL): UCVA 0.11 to 0.5, BSCVA: 0.41 to 0.78. • Statistically group B did better in all fields evaluated. www.brilliantvision.com

  7. Clinical signs of CXL www.brilliantvision.com

  8. A 24 y/oPre: UCVA 20/200 -4.5 -1.50 X 180 20/302 months post: UCVA 20/20 -0.25 -0.75 X34 www.brilliantvision.com

  9. Conclusions: • In this study we showed that UVA CXL following a limited topo-guided PRK may be a safe treatment to stabilize KCN and post-LASIK ectasia. • Visual rehabilitation has been very gratifying • Most treatments delivered more than planned > need for underscoring nomogram • Our therapeutic goal has not been emmetropia, but normalization of the cornea and improvement in BSCVA www.brilliantvision.com

  10. Conclusions Sequential tPRK and CCL appear to be superior to the rehabilitation of KCN. The advantages in pre-treating with the topo-guided PRK are: • 1- just one procedure • 2-less PRK associated scarring • 3-No need to remove cross-linked cornea • This technique may prevent PK as a necessary option and may have wide application • Longer follow-up and further studies are necessary www.brilliantvision.com

  11. Thank you www.brilliantvision.com www.brilliantvision.com

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