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Potent Inhibition of Tumor Growth by RHOXF2-shRNA in NCI-H1299 and SW1353 Cell Lines

This study demonstrates significant percentage inhibition by RHOXF2-shRNA in NCI-H1299 and SW1353 cell lines treated with cisplatin and mitomycin C. The results indicate promising therapeutic potential in cancer treatment.

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Potent Inhibition of Tumor Growth by RHOXF2-shRNA in NCI-H1299 and SW1353 Cell Lines

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  1. a b HPAC HPAC Percentage inhibition Percentage inhibition 0.00 0.01 0.03 0.13 0.5 2 8 32 0.01 0.05 0.25 1 4 16 64 256 [cisplatin] (μM) [mitomycin C] (μM) c d e NCI-H1299 NCI-H1299 RHOXF2-shRNA_1 RHOXF2-shRNA_2 RHOXF2-shRNA_3 RHOXF2-shRNA_4 RHOXF2-shRNA_5 GFP-shRNA_2 GFP-shRNA_3 Percentage inhibition WT Percentage inhibition RHOXF2 tubulin NCI-H1299 0.00 0.01 0.03 0.13 0.5 2 8 32 0.01 0.05 0.25 1 4 16 64 256 [cisplatin] (μM) [mitomycin C] (μM) f g h SW1353 SW1353 RHOXF2-shRNA_1 RHOXF2-shRNA_2 RHOXF2-shRNA_3 RHOXF2-shRNA_4 RHOXF2-shRNA_5 GFP-shRNA_2 GFP-shRNA_3 Percentage inhibition Percentage inhibition WT RHOXF2_shRNA RHOXF2_shRNA RHOXF2_shRNA RHOXF2_shRNA RHOXF2_shRNA RHOXF2_shRNA GFP_shRNA GFP_shRNA GFP_shRNA GFP_shRNA GFP_shRNA GFP_shRNA RHOXF2 tubulin SW1353 0 0.02 0.06 0.25 1 4 16 Additional File 12 [cisplatin] (μM) [mitomycin C] (μM)

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