'Gene segments' presentation slideshows

Chapter 5 Organization and Expression of Ig Genes

Chapter 5 Organization and Expression of Ig Genes. l chain. k chain (n= ~85). H chain (n= ~134). Unique features of Ig genes (1) Vertebrates can respond to a limitless array of foreign proteins. Every Ab molecule contains a unique a.a.sequence

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Overview of B-Cell Development

Micro 297 Graduate Immunology Lecture 15 Development of B Lymphocytes I Generation of Antibody Diversity Thursday August 14, 2003 Michael Wolcott READING Chapter 7. Overview of B-Cell Development. Generation of Lymphocyte Antigen Receptor.

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Acquired alterations of IGH and TCR loci in lymphoproliferative disorders

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BCR(membrane type) and secretory type Ig

B cells I. Differentiation of B cells in Bone marrow II. BCR and B cell accessory molecules III. The subsets of B cells. I. Differentiation of B cells in Bone marrow 1. process of B cell maturation 2. events in the differentiation of B cells 3. mechanisms of Ig diversity.

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Acquired alterations of IGH and TCR loci in lymphoproliferative disorders

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Lymphocyte Development & Generation of Lymphocyte Antigen Receptors

Lymphocyte Development & Generation of Lymphocyte Antigen Receptors. Pin Ling ( ? ? ), Ph.D. ext 5632; lingpin@mail.ncku.edu.tw References: 1. Abbas, A, K. et.al, Cellular and Molecular Immunology (6th ed., 2007), Chapter 8. Questions. What is the Bare Lymphocyte Syndrome?.

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MHC and TCR

BIOCHEMISTRY

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Lymphocyte Development & Generation of Lymphocyte Antigen Receptors

Lymphocyte Development & Generation of Lymphocyte Antigen Receptors. Pin Ling ( ? ? ), Ph.D. ext 5632; lingpin@mail.ncku.edu.tw References: 1. Abbas, A, K. et.al, Cellular and Molecular Immunology (6th ed., 2007), Chapter 8. Questions. What is the Bare Lymphocyte Syndrome?.

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Immunoglobulin Superfamily of Genes and Diversity of Antigen Recognition

Immunoglobulin Superfamily of Genes and Diversity of Antigen Recognition. Outline. Immunoglobulin Superfamily Antigen Recognition Members: Antibodies T-Cell Receptor Immense Diversity: The Problem: Package all that Information The Solution: Somatic Recombination

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Aims

Aims. Gene rearrangement and class switching of B-cell Igs. T cell receptors- What are they and where do they fit into immunology? Gene rearrangement to generate diversity Readings: Abbas & Lichtman, Chapters 4 & 7. Human Immunoglobulin Loci. Heavy Chain. Light Chain.

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Chapter 9 T-Cell Receptor

Chapter 9 T-Cell Receptor. Self-MHC Restriction of the TCR. Structure of TCR. Structural Similarity between TCR and mIgM. ? Resembling Fab?. Organization and Rearrangement of TCR Genes. Identifying and Cloning the TCR Genes (Hedrick and Davis, 1984)

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The Organization and Expression of Ig Genes

The Organization and Expression of Ig Genes. Justin Walter Immunology, Fall 2008. Introduction . The vertebrate immune system is capable of responding to an essentially infinite array of foreign antigens Variable vs. constant regions

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Figure 21.1

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MICR 304 Immunology & Serology

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LIGHT CHAIN

C. n. t. n. Ig Polypeptides Are Encoded by Multiple Gene Segments. LIGHT CHAIN. Polypeptide. Light Chain POLYPEPTIDE. Gene Segments. Light Chain GENE SEGMENTS. HEAVY CHAIN. o. s. a. t. Polypeptide. V. a. r. i. a. b. l. e. H.C.POLYPEPTIDE. C. C. C. V. Gene Segments.

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Announcements

Announcements. Case Studies: Case 10, 11, & 12 provided.. Please do case study 10 & 12 only. Case 11 was provided for information that may assist with Case 12. Due Feb 15, 2008 Exam 2: Wed Feb 20, 2008. Ch. 2 & 4. Class Switching occurs as the B cells are stimulated by Ag.

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Organization and Expression of Immunoglobulin Genes

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Molecular Evolution Sylvia Nagl

Molecular Evolution Sylvia Nagl. Sequence-structure-function paradigm. Relationships between DNA or amino acid sequence 3D structure protein functions Use of this knowledge for prediction of function, molecular modelling, and design (e.g., new therapies).

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Immunology II

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Reoviruses, Rotaviruses and Caliciviruses

Reoviruses, Rotaviruses and Caliciviruses. Chapter 37. Properties of Reoviruses. Structure Icosahedral, 60-80 nm, double capsid shell Segmented , double-stranded RNA; 16-27 kb 9 structural proteins, several enzymes packaged in virus Nonenveloped Cytoplasmic replication Extremely stable

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