'Human liver microsomes' presentation slideshows

Biotransformation of Xenobiotics

Biotransformation of Xenobiotics. Barbara M. Davit, PhD, DABT Division of Bioequivalence, Office of Generic Drugs, CDER, FDA Introduction to the Theory and Methods in Toxicology Sept. 17, 2001. Overview. Major Phase I and Phase II enzymes Reaction mechanisms, substrates

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CONCLUSIONS

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Identification of metabolites of actinomycin-D in vivo and in vitro

Structure of Actinomycin-D. Hydroxylation (M+H) + = 1271. Sulfonation (M+H) + = 1351. Glucuronidation (M+H) + = 1457. Peptide Cleavages (M+H) + = 327. Cyclic Peptide Cleavage (M+H) + = 971. Peptide Bond Cleavage (M+H) + = 1273.

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