'Signal sequence' presentation slideshows

Human Physiology: Endomembrane system

Human Physiology: Endomembrane system. BY DR BOOMINATHAN Ph.D. M.Sc.,(Med. Bio, JIPMER), M.Sc.,(FGSWI, Israel), Ph.D (NUS, SINGAPORE) PONDICHERRY UNIVERSITY III Lecture 9/August/2012.

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Subcellular compartments and protein targeting Alex van der Bliek

Subcellular compartments and protein targeting Alex van der Bliek. Cellular compartments. TGN. early endosome. Golgi. peroxisomes. late endosome or MVB. ERGIC. ER. lysosome. mitochondria. Compartments allow for: Specialized environments Vectorial processing

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~50% of the cell volume is in membrane bound organelles

~50% of the cell volume is in membrane bound organelles. Each organelle performs specific functions. Organelle Main function Structure Organisms Chloroplast photosynthesis double-memb. Plants, protists ER modification, folding single-memb. All eukaryotes

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3

3. Cells: The Living Units: Part A. Erythrocytes. Fibroblasts. Epithelial cells. (a) Cells that connect body parts, form linings, or transport gases. Nerve cell. Skeletal Muscle cell. (e) Cell that gathers information and control body functions. Smooth muscle cells.

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10 Protein Sorting and Transport

10 Protein Sorting and Transport. Chapt. 10: Protein Sorting, Transport: Endoplasmic Reticulum, Golgi, Lysosomes Student learning outcomes: organelle functions Explain sorting of proteins: free vs. bound ribosomes Identify signals on proteins that identify destinations:

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Neurotransmitters

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The Protein Targeting

The Protein Targeting. Prof. V.L. Maheshwari Director, School of Life Sciences North Maharashtra University, Jalgaon. The central Dogma. DNA RNA Protein. Replication. Transcription. Reverse Transcription. Translation. Protein Biosynthesis. Major Requirements are Ribosomes

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Cancer Dormancy

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Unit 7 Endomembranes

Unit 7 Endomembranes. Unit 7. SECRETORY PATHWAY:. Secretory Pathway. Proteins are synthesized on the Rough ER. Move via vesicles to Golgi Move via vesicles to Plasma membrane. Budding is through coated vesicles (ie. clathrin) Docking is through the SNAREs. Budding via Coated Vesicle.

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PML: Toward a High-Level Formal Language for Biological Systems

PML: Toward a High-Level Formal Language for Biological Systems. Bor-Yuh Evan Chang and Manu Sridharan July 24, 2003. Why Formal Models for Biology?. Experiments have led to an enormous wealth of (detailed) knowledge but in a fragmented form serve as a common language for sharing

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Protein degradation rate varies 100x

Protein degradation rate varies 100x Most have motifs marking them for polyubiquitination : taken to proteosome & destroyed Other signals for selective degradation include PEST & KFERQ PEST : found in many rapidly degraded proteins Deletion increases t 1/2 10x, adding PEST drops t 1/2 10x

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Lesson 3: Translation

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Regrades need to be typed and turned in next TUESDAY after class

Regrades need to be typed and turned in next TUESDAY after class. X-ray structure of a protein-conducting channel. Secreted Proteins. Have a special sequence on them called a signal sequence, which directs them to Endoplasmic Reticulum

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A immune-response molecule which limits trypanosome infection of tsetse midguts.

A immune-response molecule which limits trypanosome infection of tsetse midguts. Mike Lehane Liverpool School of Tropical Medicine. Midgut establishment. 1. Complex differentiation to asymmetric dividing epimastigote + migration. 2. T. brucei development in the tsetse fly. 3.

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Molecular Basis for Relationship between Genotype and Phenotype

Molecular Basis for Relationship between Genotype and Phenotype. genotype. DNA. DNA sequence. transcription. RNA. translation. amino acid sequence. protein. function. phenotype. organism. Molecular Basis for Relationship between Genotype and Phenotype. genotype. DNA. DNA sequence.

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For membrane proteins , targeting leads to insertion of the protein into the lipid bilayer

Protein targeting or Protein sorting Refer Page 1068 to 1074 Principles of Biochemistry by Lehninger & Page 663 Baltimore Mol Cell Biology. Protein targeting or Protein sorting is the process of delivery of newly synthesized proteins to their proper cellular destinations

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Molecular Basis for Relationship between Genotype and Phenotype

Molecular Basis for Relationship between Genotype and Phenotype. genotype. DNA. DNA sequence. transcription. RNA. translation. amino acid sequence. protein. function. phenotype. organism. Molecular Basis for Relationship between Genotype and Phenotype. genotype. DNA. DNA sequence.

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ntri.tamuk/cell/ribosomes.html

http://ntri.tamuk.edu/cell/ribosomes.html. 17.1, 676 How does everything get to where it has to go?. First, how does a protein fold that stays in cytoplasm? 3.14, 64. A very small percentage of proteins fold spontaneously into the right shape after being translated-

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PROTEIN TRAFFICKING AND LOCALIZATION

PROTEIN TRAFFICKING AND LOCALIZATION. PROTEINS SYNTHESIZED IN CYTOPLASM, BUT BECOME LOCALIZED IN CYTOPLASM CYTOPLASMIC MEMBRANE PERIPLASM OUTER MEMBRANE RELEASED IN ENVIRONMENT HOW? WHAT IS MECHANISM(S) OF LOCALIZATION?.

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