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Stopping rule approach - PowerPoint PPT Presentation

METHODS Number of patients : fixed sample size: 20 patients or Stopping rule approach: ? 30 for 5 doses or ? 48 patients for 8 doses, until the toxicity rate at the MTD is within (10% - 35%) Clinical outcome : Dose Limiting Toxicity (yes/no)

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Stopping rule approach - PowerPoint PPT Presentation