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Toxicity screen - PowerPoint PPT Presentation

Schizophrenia

Schizophrenia

Schizophrenia. Unfolding Case Study By Amanda Eymard , DNS, RN and Linda Manfrin-Ledet , DNS, APRN. Assigned Reading to be completed prior to case study. Prior to conducting this unfolding case study, students should read the following:

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Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

A series of novel 1,3,4-oxadiazole derivatives of phthalimide (4a-j) were prepared in satisfactory yields and evaluated for their anticonvulsant and neurotoxicity studies. All the compounds were in good agreement with elemental analysis and spectral data. All the compounds were active in MES screen and less neurotoxic than phenytoin. Compound 4j having methoxy substitution at para position of the distal aryl ring emerged as most promising anticonvulsant agent with low neurotoxicity.

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133 views • 10 slides
Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

Synthesis, anticonvulsant and neurotoxicity of some novel 1,3,4-oxadiazole derivatives of phthalimide

A series of novel 1,3,4-oxadiazole derivatives of phthalimide (4a-j) were prepared in satisfactory yields and evaluated for their anticonvulsant and neurotoxicity studies. All the compounds were in good agreement with elemental analysis and spectral data. All the compounds were active in MES screen and less neurotoxic than phenytoin. Compound 4j having methoxy substitution at para position of the distal aryl ring emerged as most promising anticonvulsant agent with low neurotoxicity.

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119 views • 10 slides

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