1 / 9

HTLV 1 & 2

HTLV 1 & 2. What are these things?. HTLV 1 & 2. T-cell Leukaemia/Lymphotropic Viruses. Occur in both Old World primates and Humans. The primate varieties are called Simian T-cell Leukemia/Lymphotropic Viruses. (STLV) The human varieties are HTLV. HTLV 1 & 2. STLV. Occurs as type 1 & 2.

shani
Download Presentation

HTLV 1 & 2

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. HTLV 1 & 2 What are these things?

  2. HTLV 1 & 2 • T-cell Leukaemia/Lymphotropic Viruses. • Occur in both Old World primates and Humans. • The primate varieties are called Simian T-cell Leukemia/Lymphotropic Viruses. (STLV) • The human varieties are HTLV.

  3. HTLV 1 & 2 • STLV. Occurs as type 1 & 2. • STLV 1 is confined to Africa and Asia in about 19 species of primates. • Distribution of STLV 2 is virtually unknown.

  4. HTLV 1 & 2 • Transmission of these agents, primate and human. • Sexual contact (type 2 may be poorly transmitted sexually) • Breast feeding • Blood transfusions (humans) • I.V drug use with needle sharing (humans)

  5. HTLV 1 & 2 • Interesting distribution pattern • Type 1. Worldwide. 15-20 million people infected. • Local regions of high prevalence • S. Japan • Caribbean • Tropical Africa

  6. HTLV 1 & 2 • Type 2 distribution • Originally thought to be New World and brought in by human migrations 10-20k years ago. • However also found in the oldest human ethnic group… Pygmy group from central Africa. • Very high rates of infection in IV drug users.

  7. HTLV 1 & 2

  8. HTLV 1 & 2 • HTLV 1 &2 are classified in the family Retroviridae. • Single stranded RNA viruses. • Reverse transcriptase. • Integrates into the host genome, lifelong infection, evades the immune system of the host.

  9. HTLV 1 & 2 • HTLV 1. adult T-cell Leukaemia/lymphoma, and a rare myelopathy also known as tropical spastic parapariesis. Infective dermatitis of children and also uveitis. Lots of speculation in terms of other diseases. • HTLV 2. Myelopathy?, no leukaemia/lymphoma no other convincing disease associations but lots of speculation.

More Related