1 / 4

ESM technology: enhancing drug performance

ESM technology: enhancing drug performance. Neutral molecules pass freely through cell. Pharmacokinetics limited by clearance from plasma. Intracellular target. “Parent” molecule. ESM technology: enhancing drug performance. Linking motif to parent creates novel IP.

shiri
Download Presentation

ESM technology: enhancing drug performance

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. ESM technology: enhancing drug performance • Neutral molecules • pass freely through cell • Pharmacokinetics • limited by clearance • from plasma Intracellular target “Parent” molecule

  2. ESM technology: enhancing drug performance • Linking motif to parent • creates novel IP • Neutral parent/motif is • cell permeable Intracellular target

  3. Family of three • enzymes • Expression of • one is restricted • to macrophages ESM technology: enhancing drug performance • Linking motif to parent • creates novel IP • Neutral parent/motif is • cell permeable • Motif cleaved by • intracellular enzyme • leaving charged species ± Intracellular target • Charged species also • novel/patentable • Charged species • accumulates in cell

  4. Back

More Related