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Treating Tobacco Use and Dependence

Treating Tobacco Use and Dependence. July 2006. Learning Objectives. At the end of this session you should understand: The impact of tobacco dependence Tobacco dependence as a chronic disease Clinical interventions for tobacco users willing to quit

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Treating Tobacco Use and Dependence

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  1. Treating Tobacco Use and Dependence July 2006

  2. Learning Objectives At the end of this session you should understand: • The impact of tobacco dependence • Tobacco dependence as a chronic disease • Clinical interventions for tobacco users willing to quit • Clinical interventions for tobacco users not willing to make a quit attempt

  3. Why should I treat tobacco dependence? • Tobacco causes premature death of almost half a million Americans each year • 1/3 of all tobacco users in this country will die prematurely from tobacco dependence losing an average of 14 years • 70% of smokers see a physician each year • 70% of smokers want to quit

  4. Are physicians intervening in tobacco use? In 38 primary care practices: Tobacco was discussed in 21% of encounters. Discussion was: • more common in the 58% of practices with standard forms for recording smoking status • more common during new patient visits • less common with older patients • less common with physicians in practice more than 10 years. Ellerbeck, Ahluwalia, et al. Direct observation of smoking cessation activities in primary care practice. J Fam Pract. 2001;50:688-693

  5. Barriers to treating tobacco dependence “Not enough time.” “Patients don’t want to hear about it.” “I can’t help patients stop.”

  6. “Not enough time” “Minimal interventions lasting less than 3 minutes increase overall tobacco abstinence rates.” The PHS Guideline (Strength of Evidence = A)

  7. “Patients don’t want to hear about it” “Smoking cessation interventions during physician visits were associated with increased patient satisfaction with their care among those who smoke.” 1,898 patients in a study who reported that they had been asked about tobacco use or advised to quit during the latest visit had 10%greater satisfaction rating and 5% less dissatisfaction than those not reporting such discussions Mayo Clin Proc. 2001;76:138-143.

  8. “I can’t help patients stop” Effective clinical interventions exist: The Public Health Service Clinical Practice Guideline Treating Tobacco Use and Dependencewas published in June, 2000 and offers effective treatments for tobacco dependence.

  9. Tobacco dependence is achronic disease • Tobacco dependence requires ongoing rather than acute care • Relapse is a component of the chronic nature of the nicotine dependence — not an indication of personal failure by the patient or the clinician

  10. Tobacco results in a true drug dependence • Tobacco dependence exhibits classic characteristics of drug dependence • Nicotine is: • Causes physical dependence characterized by withdrawal symptoms upon cessation • Psychoactive • Tolerance producing

  11. How do I treat tobacco users who are willing to quit?

  12. The 5 A’sFor Patients Willing To Quit • ASKabout tobacco use. • ADVISEto quit. • ASSESSwillingness to make a quit attempt. • ASSISTin quit attempt. • ARRANGEfor follow-up.

  13. ASK EVERY patient at EVERY visit

  14. ADVISE • Once tobacco use status has been identified and documented, advise all tobacco users to quit • Even brief advice to quit results in greater quit rates • Advice should be: • clear • strong • personalized “As your health care provider, I must tell you that the most important thing you can do to improve your health is to stop smoking.”

  15. ASSESS After providing aclear, strong, andpersonalized message to quit, you must determine whether the patient is willing to quit at this time. “Are you willing to try to quit at this time? I can help you.”

  16. ASSIST • Help develop a quit plan • Provide practical counseling • Provide intra-treatment social support • Help your patient obtain extra-treatment social support • Recommend pharmacotherapy except in special circumstances • Provide supplementary materials

  17. Developing a quit plan • Set a quit date • Review past quit attempts • Anticipate challenges • Remove tobacco products • Avoid • Alcohol use • Exposure to tobacco

  18. How do I counsel patients to quit?

  19. Counsel your patients to quit “Minimal interventions lasting less than 3 minutes increase overall tobacco abstinence rates” The PHS Guideline (Strength of Evidence = A) “There is a strong dose-response relation between the session length of person-to- person contact and successful treatment outcomes. Intensive interventions are more effective than less intensive interventions and should be used whenever possible.” The PHS Guideline (Strength of Evidence = A)

  20. What pharmacotherapies are available to ASSIST in the quit attempt? By using the pharmacotherapies found to be effective in the PHS Guideline, you can double or triple your patients’ chances of abstinence.

  21. First-line pharmacotherapies • Bupropion SR (Zyban, Welbutrin) • Nicotine gum • Nicotine inhaler • Nicotine nasal spray • Nicotine lozenge • Nicotine patch • Varenicline (Chantix)

  22. Bupropion SR • One of two non-nicotine medications approved by the FDA as an aid to smoking cessation treatment • Available by prescription only (USA) • Mechanism of action: presumably blocks neural reuptake of dopamine

  23. Bupropion SR Contraindications: • Seizure disorder • MAO inhibitor used within previous 2 weeks • Hx of anorexia nervosa or bulimia • Current use of Wellbutrin Side effects: • Insomnia • Dry mouth

  24. Bupropion SR Dosing: • start 1-2 weeks before quit date • 150 mg orally once daily x 3 day • 150 mg orally twice daily x 7-12 weeks • no taper necessary at end of treatment Maintenance: • efficacious as maintenance medication for <6 months post-cessation

  25. Varenicline (Chantix) • New medication was FDA-approved in May 2006and on the market July 2006 • Varenicline, a pill, is available by prescription only • Varenicline is neither a nicotine replacement therapy nor an anti-depressant drug • Unique: Varenicline acts on nicotine receptors with two types of action: It blocks some of the rewarding effects of nicotine (acts as an antagonist) and at the same time stimulates the receptors in a way that reduces withdrawal (acts as an agonist).

  26. Varenicline (Chantix) Side Effects: • Generally well tolerated • The most common side effects are nausea, headache, trouble sleeping and abnormal dreams Dosage: • Start varenicline one week before the quit date for maximum effectiveness. Recommended treatment is 12 weeks: • ⇒ Days 1-3: …………….1 pill (0.5 mg) per day; • ⇒ Days 4-7: …………….1 pill (0.5 mg) twice a day (a.m. and p.m.) • ⇒ Day 8 to the end: ……1 pill (1 mg) twice a day (a.m. and p.m.) • For best results, quit smoking on Day 8 • An additional course of 12 weeks for maintenance can be considered. Pfizer pre-packages Chantix so the pills are laid out day-by-day, in a “Starting Month” package (four weeks) and “Continuing Month” packages thereafter.

  27. Varenicline (Chantix) Precautions: • Use with caution and consider dose reduction in patients: • With significant renal impairment • Undergoing dialysis Cost Varies: • Cost varies, but it is approximately $120 per month ($4 per day). • Varenicline is covered by many health care plans.

  28. Nicotine Replacement Therapy (NRT) • Nicotine is active ingredient • Supplied as steady dose (patch) or self-administered (gum, inhaler, nasal spray) • Self-administered products should be used on scheduled basis initially before tapered to ad lib use and eventual discontinuation

  29. Nicotine Replacement Therapy (NRT) • No evidence of increased cardiovascular risk with NRT • Medical contraindications: • immediate myocardial infarction (< 2 weeks) • serious arrhythmia • serious or worsening angina pectoris • accelerated hypertension

  30. Nicotine Replacement Therapy (NRT) • Nicotine gum • Nicotine patch • Nicotine inhaler • Nicotine nasal spray • Nicotine lozenge

  31. Nicotine gum • 2 mg vs. 4 mg • Chew and park • Absorbed in a basic environment • Use enough pieces each day

  32. Nicotine patch • Available as both prescription and OTC • A new patch is applied each morning • Rotating placement site can reduce irritation

  33. Nicotine inhaler • Available by prescription • Frequent puffing is required • Eating or drinking before and during administration should be avoided

  34. Nicotine nasal spray • Available by prescription • Patient should not sniff, swallow, or inhale the medication • Initial dosing should be 1 to 2 doses per hour, increasing as needed • Dosing should not exceed 40 per day

  35. Nicotine lozenge • Available over the counter • Treatment period is up to 12 weeks • Lozenges should not be chewed or swallowed, but should slowly dissolve in the mouth • Dosage: 2mg or 4 mg (if smoke less than 30 minutes after waking) • Use lozenges on a regular schedule, using at least 9 lozenges per day during the first 6 weeks

  36. Combination Pharmacotherapy • Combination NRT • Patch + gum or patch + nasal spray are more effective than a single NRT • Encourage use in patients unable to quit using single agent • Caution patients on risk of nicotine overdose • Currently, not an FDA-approved treatment option

  37. ARRANGE • Schedule a follow-up contact within one week after the quit date • Telephone contact • Quit lines • The majority of relapse occurs in the first two weeks after quitting

  38. The Quit Line and the 5 A’s • ASKabout tobacco use. • ADVISEto quit. • ASSESSwillingness to make a quit attempt. • ASSISTin quit attempt. • ARRANGEfollow-up.

  39. Relapse • Preventing Relapse • Congratulate success • Encourage continued abstinence • Discuss with your patient: • benefits of quitting • barriers • If your patient has used tobacco, remind him or her that the relapse should be viewed as a learning experience • Relapse is consistent with the chronic nature of tobacco dependence; not a sign of failure “How has stopping tobacco use helped you?”

  40. How do I treat tobacco users who are not willing to make a quit attempt?

  41. Treating patients who are not ready to make a quit attempt • RELEVANCE: Tailor advice and discussion to each patient. • RISKS: Outline risks of continued smoking. • REWARDS: Outline the benefits of quitting. • ROADBLOCKS: Identify barriers to quitting. • REPETITION: Reinforce the motivational message at every visit.

  42. Assessment of Tobacco Use Patient presents to a health care provider Does patient currently use tobacco? YES NO Is the patient currently willing to quit? Did the patient previously use tobacco? YES NO YES NO Provide appropriate treatments (5 As) Promote motivation to quit (5 Rs) Prevent relapse Encourage continuedabstinence

  43. Web Sites • USPHS Guideline and materials:www.surgeongeneral.gov/tobacco • Wisconsin Tobacco Control:www.tobwis.org • UW-Center for Tobacco Research & Intervention:www.ctri.wisc.edu

  44. www.ctri.wisc.edu“Not since the polio vaccine has this nation had a better opportunity to make a significant impact in public health.”David Satcher, MD, PhD,Former U.S. Surgeon General

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