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Citric Acid Cycle (C.A.C.)

Citric Acid Cycle (C.A.C.). Mitochondrial Structure (cont.). TCA Cycle. O. Co - ASH. ||. Step 1. CH 3. C. S. CoA. O. C. C. O. O. O -. C. C. Citrate Synthase. O. O -. OH. C. C. O -. O. C. C. O. O -. C. C. O -. Oxaloacetate. Citrate (3° Alcohol). Step 2 & 3. O.

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Citric Acid Cycle (C.A.C.)

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  1. Citric Acid Cycle (C.A.C.)

  2. Mitochondrial Structure (cont.)

  3. TCA Cycle

  4. O Co - ASH || Step 1 CH3 C S CoA O C C O O O- C C Citrate Synthase O O- OH C C O- O C C O O- C C O- Oxaloacetate Citrate (3° Alcohol)

  5. Step 2 & 3 O O O C C C C C C H2O O- O- O- O O O HO C C C C H C C O- O- O- O O O C C C C HO C C H Aconitase O- O- O- Citrate Aconitate Isocitrate (2° alcohol)

  6. Step 4 O O C C C C O- O- O O C C C C O- O- NAD+ NADH + H+ O O HO C C Isocitrate Dehydrogenase C C O O- O- H Oxalosuccinate Isocitrate CONT. NEXT SLIDE

  7. Step 5 Classic biological redox Rx. 2° alcohol oxidized to a keto NAD+ reduced. CO2 O C C O- • Carboxylic acids that are  to a keto group spontaneously decarboxylate. C O C C O O-  - keto glutarate

  8. Step 6 O O CO2 C C C C CoASH O- O- PGTP = 8 Kcal/m C C NAD+ NADH + H+ O CoA C C C S O O O-  - keto dehydrogenase  - keto glutarate Succinate Co-A CONT. NEXT SLIDE

  9. H2O GDP ATP CoASH ADP GTP O C C Succinate Synthetase Step 7 O- C C O O- Succinate

  10. Step 8, 9, 10 O O O O C FAD FADH2 C NAOD + H+ C C NAD+ O - HOH O - O - O - C H C H H C HO C O H C H H C H C H H C O O O O S.D.H Fumarase M.D.H C C C C O - O - O - O - Succinate Fumarate Malate O.A.A Trans Dehydrogenation 2° Alcohol Oxidized to keto NADH +

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