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Virus

Virus . Skin viral infection. Difinition & classification. classification. DNA viruses. RNA virused. Picorna viruses: coxackie , rubella. Echo viruses: hand foot mouth diseases. Herpes viruses(7types) Pox viruses: molluscum contagiosum , orf , variola .. Papova viruses: warts.

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Virus

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  1. Virus

  2. Skin viral infection Difinition & classification

  3. classification DNA viruses RNA virused Picorna viruses: coxackie, rubella. Echo viruses: hand foot mouth diseases • Herpes viruses(7types) • Pox viruses: molluscumcontagiosum, orf, variola.. • Papova viruses: warts

  4. Herpes simplex • Etiology • Clinical feature • Complication • Recurrent infection • Predisposing factors • treatment

  5. Common and important herpesviruses of humans include herpes simplex virus types 1 and 2, varicella-zoster virus, Epstein-Barr (EB) virus, and cytomegalovirus. Properties of the Viruses:Allherpesviruses have a core of double-stranded DNA surrounded by a protein coat that exhibits icosahedral symmetry. The nucleocapsid is surrounded by an envelope.

  6. Clinical feature • Herpes facialis

  7. Clinical features

  8. H.S. buccalis (gingivostomatitis)

  9. H.S. Buccalis

  10. Genital herpes (herpes progenitalis). Genital herpes is characterized by vesiculoulcerative lesions of the penis of the male or the cervix, vulva, vagina, and perineum of the female. The lesions are more severe during primary infection and may be associated with fever, malaise, and inguinal lymphadenopathy. Type 2 virus remains latent in lumbar and sacral ganglia.

  11. Herpes progenitalis

  12. complication • Erythema multiform • Disseminated cutaneous HSV infection • Eczema herpeticum • Herpes simplex keratitis • Herpetic encephalitis

  13. Mother with cold sore on lip holding baby with eczema herpeticum Eczema Harpaticum

  14. disseminated H.S. (with lymphoma)

  15. Keratoconjunctivitis. The initial infection with herpesvirus may be in the eye, producing severe keratoconjunctivitis. Recurrent lesions of the eye appear as dendritickeratitis or corneal ulcers or as vesicles on the eyelids. With recurrent keratitis, there may be progressive involvement of the corneal stroma, with permanent opacification and blindness.

  16. Recurrent infection and its predisposition factors

  17. treatment • Local treatment • Systemic treatment

  18. Herpes zoster or Zona Etiology & Epidemiology

  19. HZ histopathology • Intraepidermal vesicle • Multinucleated giant cells

  20. Clinical manifestations HZ vesicule HZ histopathology

  21. Clinical features • Zonabullosa • Zonahaemorrhagic • Zonagangrenosa • Ramsay hunt syndrom

  22. Zonagangrenosa and scar formation and muscle weakening

  23. Zonaophthalmica • Hutchison’s sign

  24. complications • PHN • Secondary bacterial infection • Disseminated lesion formation • Motor paralysis or muscular paralysis • Encephalitis and meningoencephalitis • Guillainbarrsyndrom • Acute necrotic syndrom of retina

  25. Disseminated zona in leukemic patient

  26. managment • Local treatment • Systemic treatment: • Antiviral drugs • Corticosteroids • Amitriptylin • Analgesic • Gabapentin and capsaicin • nerve block • Acyclovir 800mg/5 times in a day • Valacyclovir 1g/3 times in a day • Famacyclovir 500mg/3 times a day for7-10days

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