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Whole genome analysis

Whole genome analysis. Whole genome sequencing – initial pass Re-sequencing Analysis of duplications within a genome Comparative genomics – two or more genomes Next, SNPs – population studies. questions. What changes more slowly – ORFs or intergenic regions? Why?

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Whole genome analysis

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  1. Whole genome analysis • Whole genome sequencing – initial pass • Re-sequencing • Analysis of duplications within a genome • Comparative genomics – two or more genomes • Next, SNPs – population studies

  2. questions • What changes more slowly – ORFs or intergenic regions? • Why? • Could you do this analysis with yeast and humans? What would you use to do this analysis for the human genome?

  3. Good example introduction for the paper you will write: Set up the problem

  4. What is the question? What does this show? What is the word used to describe this conservation of gene position?

  5. What is the question? What does this show? Why do you think these events are clustered?

  6. What was the question? What does this show? Is this consistent with our hypothesis about gene and non-gene evolution?

  7. What was the question? What does this show? What is Ka and Ks?

  8. What is the question? Why is this harder?

  9. What questions might you ask next?

  10. Note the role of annotation in this discovery process

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