1 / 78

Immunomodulation in Homotoxicology

Immunomodulation in Homotoxicology. Juan Carlos Herrera Correa, MD. Immunological tolerance. Hyporeactivity or non-reactivity of the immune system to an antigen, induced by previous contact with this antigen. IL 10. -TGF. Tolerogenic. Reparative. MALT. MALT. NALT LALT BALT GALT

taurean
Download Presentation

Immunomodulation in Homotoxicology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Immunomodulation in Homotoxicology Juan Carlos Herrera Correa, MD

  2. Immunological tolerance Hyporeactivity or non-reactivity of the immune system to an antigen, induced by previous contact with this antigen Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  3. IL 10 • -TGF Tolerogenic Reparative

  4. MALT

  5. MALT NALT LALT BALT GALT SALT

  6. Czerkinsky, Cecil; Anjuere, Fabienne; McGhee, Jerry R.; George-Chandy, Annie; Holmgren, Jan; Kieny, Marie-Paule; Fujiyashi, Kohtaro; Mestecky, Jiri F.; Pierrefite-Carle, Valérie; Rask, Carola; Sun, Jia-Bin. Mucosal immunity and tolerance: relevance to vaccine development. Immunological Reviews. Volume 170 August 1999 pp 197-222.

  7. Mucosa-Associated Lymphoid Tissues Brandtzaeg, P. Homing of mucosal immune cells-a possible connection between intestinal and articular inflammation. Alimentary pharmacology & Therapeutics, Supplement. Volume 11 Supplement 3  December 1997 pp 24-39. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  8. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  9. Patients who are allergic to cow’s milk show increased intestinal permeability. • Van Elburg RM, Heymans HS, De Monchy JG. Effect of disodium cromoglycate on intestinal permeability changes and clinical response during cow’s milk challenge. Pediatr Allergy Immunol 1993; 4:79–85. • Schrander JJ, Unsalan-Hooyen RW, Forget PP, et al. [51Cr] EDTA intestinal permeability in children with cow’s milk intolerance. J Pediatr Gastroenterol Nutr 1990; 10:189–92. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  10. Immunological tolerance and intestinal mucosa • Barrier mechanism: secretion of mucus • Intestinal flora • Mucosal integrity • IgA • MALT regulation mechanisms Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  11. Antigen presentation Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  12. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  13. Antigen presentation Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  14. Antigen APC Macrophage CD8 M. Rosales Sdme de Inflamación de las Mucosas. 2nd edition MHC PROCESSEDANTIGEN TCR Th0 IL-10 Th3 Th1 Th2 TGF-B IL-10 IL2, IFN-G, TNF-A IL4, IL5, IL6 IL9, IL10, IL13 Th1 B B Cell-mediated immunity Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006 IGM, IgE, IgG IGA

  15. How does the body react to the entry of an antigen? • Production of antibodies • Anergy or apoptosis • Immunological tolerance Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  16. Normal response in CD 4 + T lymphocytes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  17. Types of response Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  18. Immunological tolerance Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  19. Schmidt-Weber, C. B.; Blaser, K. T-cell tolerance in allergic response. Allergy: European Journal of Allergy and Clinical Immunology. Volume 57(9)  September 2002 pp 762–768 Swiss Institute for Allergy and Asthma Research, Switzerland

  20. Tolerance mechanisms1. Insufficient co-stimulation Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  21. Without co-adjuvants Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  22. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  23. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants3. CTLA4 receptors Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  24. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  25. “Cytolytic T lymphocytes” Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  26. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants3. CTLA4 receptors 4. Slight mutation of antigen structure Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  27. Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  28. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants3. CTLA4 receptors 4. Slight mutation of antigen structure5. APC-mediated suppression Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  29. IL 10 Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  30. Tolerance mechanisms1. Insufficient co-stimulation2. Abundant soluble antigen without adjuvants3. CTLA4 receptors 4. Slight mutation of antigen structure5. APC-mediated suppression6. Bystander suppression Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  31. Bystandersuppression Immunological bystander reaction Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  32. Immunological bystander reaction Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  33. Immunological bystander reaction (IBR) Special kind of “low dose antigen reaction” Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  34. Entry Oral Mucosa-associated lymphoid tissue MALT Other routes Immunological cells of the matrix Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  35. The potentized proteins of the medicines are immunologically challenged by antigen presenting cells Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  36. IBR Antigen presenting cells APC Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  37. IBR Phagocytosis Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  38. IBR D1-D14 Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  39. IBR Processing in proteasomes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  40. IBR Digestion by lysosomes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  41. IBR Short sequences of amino acids (9-15) Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  42. IBR Coupling to MHC class II Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  43. IBR Transport via vacuoles Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  44. IBR To the cell membrane Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  45. IBR Anchorage in glycocalyx Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  46. IBR Expression of epitopes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  47. IBR Patrolling lymphocytes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  48. IBR CD4 T lymphocytes Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

  49. IBR APC-lymphocyte complex Dr. Juan Carlos Herrera Correa_Immunomodulation_Speakers' Training 2006

More Related