Gene Mutation and Molecular Medicine

Sep 16, 2012

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15 Gene Mutation and Molecular Medicine . 15.1 What Are Mutations?15.2 How Are DNA Molecules and Mutations Analyzed?15.3 How Do Defective Proteins Lead to Diseases?15.4 What DNA Changes Lead to Genetic Diseases?15.5 How Is Genetic Screening Used to Detect Diseases?15.6 How Are Genetic Diseases

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Gene Mutation and Molecular Medicine

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1. Gene Mutation and Molecular Medicine

Gene Expression: Protein Synthesis and Genetic Mutation

Why make proteins?. Proteins are made of 20 kinds of amino acids linked together in a specific order. (2 or more polypeptides).All organisms contain and make proteins. Major structural components of your cells, and your body as a whole. i.e., keratin- hair, fingernails, hemoglobin- rbc's, insulin

1.28k views • 27 slides

Gene Mutation

Gene Mutation . Mutation. Mutation: change in DNA sequence Causes of mutation:. Spontaneous Mutation. Spontaneous mutation in gene for a blood clotting factor, leading to hemophilia. . Point Mutations. Point mutation: change in one or a few DNA nucleotides. Substitutions .

1.07k views • 22 slides

Gene Mutation

647 views • 36 slides

Recombination, Mutation, Genetic Drift, Gene Flow

Recombination, Mutation, Genetic Drift, Gene Flow. Also evolution . Recombination. Remember Meiosis? This is when recombination occurs Shuffling of chromosomes/genes/alleles Also crossing over Remember fertilization? Coming together of shuffled genes New alleles not created, just

434 views • 15 slides

Gene Mutation

Gene Mutation. *Mutation. Chromosome mutations/aberrations. Classification of Mutations. 1. Spontaneous vs. Induced Spontaneous mutation Induced mutation. 2. Gametic vs. Somatic Somatic mutation Gametic mutation. 3. Other categories. Gene Mutation.

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Molecular Basis of Mutation

Molecular Basis of Mutation. Bashdar M. Hussen MSc.Biotechnology Hawler Medical University bashdar@res.hmu.edu.iq bmhscience@yahoo.com. What Are Mutations?. Changes in the nucleotide sequence of DNA May occur in somatic cells (aren’t passed to offspring)

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Gene – Expression – Mutation - polymorphism

Gene – Expression – Mutation - polymorphism. How are genes expressed ?. DNA . Transcription . Pre-mRNA. Cap. Poly(A ) . Splicing . Lariat intron. mRNA. Cap. Poly(A) . Degradation . Nucleus . mRNA transport . Translation . Cytoplasm. Ribosome. PROTEIN . MUTATION.

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Gene Mutation

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Molecular Mechanism of Mutation

Molecular Mechanism of Mutation. Shikha Yashveer 1 , Jayanti Tokas 2, Shalini Jain 3 and Hariom Yadav 4 1 Department of Molecular Biology and Biotechnology, 2 Department of Biochemistry, CCS HAU, Hisar, Haryana, India 3 Department of Biochemistry, PGIMER, Chandigarh, India

1.31k views • 55 slides

Molecular medicine - 2

Molecular medicine - 2. Key concepts. Positional cloning in identifying disease alleles (an example – cystic fibrosis) Majority of human diseases have polygenic or multi-factorial risk factors. Challenges and approaches in the post genomic era.

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Mechanisms of Gene Mutation

Mechanisms of Gene Mutation. Lecture 7 Dr. Attya Bhatti. Molecular basis of gene mutations. Are of two types 1. Spontaneous mutations 2. Induced mutations Can be analyzed by Molecular Genetic Techniques. Spontaneous mutations. Arise from a variety of sources,

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Chapter 7 Gene Mutation and DNA Polymorphisms

Chapter 7 Gene Mutation and DNA Polymorphisms. A C A C G C A . . . T C G A G T C. A C A C G C A . . . T C G G G T C. The Challenge after Human Genome Project. Understanding the link between ï‚¾. DNA sequence (Genotype). Environment. Biology (Phenotype). 100% genetic.

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Gene Mutation, DNA Repair, and Transposition

Chapter 14 Lecture. Essentials of Genetics. Gene Mutation, DNA Repair, and Transposition. 14.1 Mutations Are Classified in Various Ways Spontaneous and Induced Mutations Classification Based on Location of Mutation Somatic Germline Autosomal X-linked

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Gene Mutation, Polymorphism, Gene mapping and identification （ From Genotype to Phenotype ）

Gene Mutation, Polymorphism, Gene mapping and identification （ From Genotype to Phenotype ）. 张咸宁 zhangxianning@zju.edu.cn Tel：13105819271; 88208367 Office: C303, Teaching Building 2014/09. http://asia.ensembl.org/. Mutations 突变.

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EGFR gene mutation testing in NSCLC

EGFR gene mutation testing in NSCLC. Rachel Butler All Wales Molecular Genetics Laboratory. Benefits of stratified medicine. Reduce adverse reactions Reduce morbidity and patient distress Reduce associated costs Improve patient response through correct dose or effective therapy

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12 Molecular Mechanisms of Mutation and DNA Repair

12 Molecular Mechanisms of Mutation and DNA Repair. Mutations . A mutation is any heritable change in the genetic material Mutations are classified in a variety of ways Most mutations are spontaneous : they are random, unpredictable events

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Molecular Medicine

Molecular medicine strives to promote the understanding of normal body functioning and disease pathogenesis at the molecular level, molecular medicine is an interdisciplinary approach to human biology. http://www.oatext.com/IntegrativeMolecularMedicine.php

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Introduction to DNA and Gene Mutation

Students will discuss how DNA works. Students discuss gene mutation.

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Heredity, Gene Regulation, and Development Mutation A. Overview

Heredity, Gene Regulation, and Development Mutation A. Overview. Mutation A. Overview 1) A mutation is a change in the genome of a cell. Mutation A. Overview 1) A mutation is a change in the genome of a cell. 2 ) Somatic Mutations:

546 views • 53 slides

Gene Mutation and Molecular Medicine

Gene Mutation and Molecular Medicine. 15 Gene Mutation and Molecular Medicine. 15.1 What Are Mutations? 15.2 What Kinds of Mutations Lead to Genetic Diseases? 15.3 How are Mutations Detected and Analyzed? 15.4 How Is Genetic Screening Used to Detect Diseases?

1.29k views • 127 slides

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