1 / 16

Linking HIV-infected infants to survival

Linking HIV-infected infants to survival. Mark Cotton Children’s Infectious Disease Clinical Research Unit (KID-CRU) Faculty of Health Sciences, Stellenbosch University & Tygerberg Children’s Hospital. Infants <6m of age in TCH - week of 30/1/06 - 3/2/06 Burden of disease. 25 infants

trina
Download Presentation

Linking HIV-infected infants to survival

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Linking HIV-infected infants to survival Mark Cotton Children’s Infectious Disease Clinical Research Unit (KID-CRU) Faculty of Health Sciences, Stellenbosch University & Tygerberg Children’s Hospital

  2. Infants <6m of age in TCH - week of 30/1/06 - 3/2/06Burden of disease • 25 infants • Median age 4m (IQ: 2.4 - 4.8) • HIV-exposed - 15 (60%) • HIV+ - 6 (24%) Not HIV HIV-infected HIV exposed uninfected

  3. AIDS 2009; 23: 101-106

  4. Annual post-neonatal deaths (X), Age 1-11 months, & antenatal HIV prevalence (%) (--), South Africa, 1990-2002

  5. Observed and fitted likely HIV/AIDS-related deaths, Age 1-11 months, South Africa, 1997-2002

  6. Non-HIV/AIDS-related deaths, Age 1-11 months, South Africa, 1997-2002

  7. N Engl J Med 2008; 359: 2233-44

  8. Screening & Enrolment Number of Participants prescreened: 5985 Number of Participants HIV+: 405 (6.8% of prescreened) Number of referred HIV+ participants: 155 Total Number of HIV+ Participants: 560 Number of Participants screened: 532 Participants enrolled CHER: 377 Participants with CD4<25%:104 (19.5%) Median 7.4 weeks of age Not enrolled for Other reasons:51

  9. Risk of death Death rate per 100 person-years (Early vs Deferred) • 3 months 10 vs 41 • 3 to 6 months 4 vs 23 • 6 to 12 months 3 vs 9

  10. South Africa • Infants born in Midwife obstetric Units or Hospitals • Referred to Community Clinics from 2 weeks if replacement feeding • At 6 weeks • Immunization • Diagnostic PCR • PCP prophylaxis • Turn-around time 1 to 2 weeks?

  11. Characteristics at start of ART: reports from sub-Saharan Africa

  12. Ikwezi Clinic • Since May 2007 • 20 or 34 infants still in care • Referred appropriately but delay care • 3 - 4m of age • 1st visit only • ARV clinic in separate building • Stigma • But slowly, clinic growing Annalize Paling - SUFHS

  13. TB exposure - infants between 3 and 4 months of age screened for TB prevention trial

  14. TB contact per 100 000 HIV-exposed infants 3-4 months of age

  15. The clock is ticking

More Related