Peptide PROTAC in Drug Development
At present, most current PROTACs use small molecules as targeting warheads, which rely heavily on POI binding pockets. With the rapid development of structural biology, it is becoming more and more convenient to obtain peptides with high affinity to POI epitopes. Therefore, the design of PROTAC based on specific peptides (p-PROTAC) is an emerging method that can achieve the specific and effective degradation of POI, and expand the scope in regards to u201cundruggableu201d proteins targeting, while avoiding the restriction of shallow binding pockets through large interacting surfaces between POI and peptides.
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