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I. Introduction The vascular endothelial growth factor (VEGF) is the most

I. Introduction The vascular endothelial growth factor (VEGF) is the most potent stimulator in lymphangiogenesis. Three single nucleotide polymorphisms (SNPs) (-2578C/A, -634G/C in the promoter region, +936C/T in 3’UTR) are related to VEGF production. We conducted a case-control study to

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I. Introduction The vascular endothelial growth factor (VEGF) is the most

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  1. I. Introduction The vascular endothelial growth factor (VEGF) is the most potent stimulator in lymphangiogenesis. Three single nucleotide polymorphisms (SNPs) (-2578C/A, -634G/C in the promoter region, +936C/T in 3’UTR) are related to VEGF production. We conducted a case-control study to evaluate the effects of these three functional SNPs on the development of thyroid cancer and lymph node metastasis. II. Result Table 1. Baseline demographics of study characteristics All three SNPs were in HWE. The A allele of SNP -2578C/A (i.e rs699947) increased a risk for thyroid cancer (adj. OR =1.36, 95%C.I =1.02~1.81, p=0.039).There was a tendency of increasing the frequency of the risk allele from controls, patients without lymph node metastasis to patients with lymph node metastasis (Ptrend=0.019). Further analysis showed the genetic effect was only in men (adj. OR=1.97, 95% C.I=1.16~3.37,p=0.013), but not in women (adj. OR=1.15, 95% C.I=0.81~1.62, p=0.435) . III. Conclusion The A allele of SNPrs699947 of the VEGF gene increases the risk of thyroid cancer development and regional lymph nodes metastasis in men. IV. Materials & Methods A total of 332 thyroid cancer patients (papillary cancer and follicular cancer) and 261 controls were recruited in this case-control study (1980~2006). The genotypes were determined by Taqman 5’nuclease assay. Hardy-Weinberg equilibrium was tested for each SNP and genetic effects were evaluated by the x2 test and multiple logistic regression. . V. Reference 1. Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat Rev Cancer, 2006;6:292-306 2. Angiogenesis in endocrine tumors. Endocr Rev, 2003, 24:600-32 Vascular endothelial growth factor gene polymorphismsin thyroid cancerMing-Ying Lu1, 2 , Pi-Jung Hsiao1*, Feng-Yu Chiang 1, Shyi-Jang Shin1 , Yu-Da Tai1, Suh-Hang Hank Juo1,1.Kaohsiung Medical University, Kaohsiung, Taiwan2. Health Center of Cimei Township, Public Health Bureau, Penghu County, TaiwanAccepted by Journal of Endocrinology, 2007 Table 2. Association between VEGF polymorphisms in thyroid cancer LN meta: lymph node metastasis P1 & P1’: Total thyroid cancer v.s Control P2 & P2’: Thyroid cancer with LN meta(+) v.s Control Trend test: Genotypes v.s LN meta(+)  LN meta(-)  Control * Missing information of histological type in 33 thyroid cancer patients ** lymph node metastasis(+): papillary cancer n=68; follicular cancer n=8 Table 3. Sex-specific association between rs699947 and thyroid cancer *Comparing total cases with controls by multiple logistic regression regression where age was adjusted and an additive mode of inheritance was assumed †P-trend: Genotypes in LN meta(+)  LN meta(-)  Control

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