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Cytopathology Challenge! Weekly Cases. Feb 1st, 2008 GYN SPECIAL EDITION NUMBER 2. 24 year old female. ThinPrep pap LSIL HSIL ASCUS Squamous Metaplasia Endocervical Cells. 1. 34 year old female. ThinPrep pap Reactive endocervical cells Squamous metaplasia ASCUS LSIL HSIL. 2.
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Cytopathology Challenge! Weekly Cases Feb 1st, 2008 GYN SPECIAL EDITION NUMBER 2
24 year old female. ThinPrep pap • LSIL • HSIL • ASCUS • Squamous Metaplasia • Endocervical Cells 1
34 year old female. ThinPrep pap • Reactive endocervical cells • Squamous metaplasia • ASCUS • LSIL • HSIL 2
34 year old female. • ThinPrep pap • ASCUS • LSIL • HSIL • Squamous Metaplasia • Reactive/Inflammatory 3
29 year old female. ThinPrep pap • Squamous metaplasia • Reactive endocervical cells • ASC-US • LSIL • HSIL 4
32 year old female. ThinPrep pap • Squamous metaplasia • Reactive endocervical cells • ASC-US • LSIL • HSIL 5
23 year old female. ThinPrep pap • Squamous metaplasia • Parakeratosis • LSIL • HSIL • SCCA 6
18 year old female. • ThinPrep pap • CMV • HIV • HPV • HSV • EBV 7
52 year old female. • ThinPrep pap • Reactive endocervical cells • Normal endometrial cells • AIS • Adenocarcinoma • HSIL 8
44 year old female. ThinPrep pap A. Squamous metaplasia B. Reactive endocervical cells C. Atrophy D. LSIL E. HSIL 9
34 year old female. ThinPrep pap • Reactive • ASCUS • LSIL • HSIL • Squamous Metaplasia 10
Answers • D Squamous Metaplasia • Nuclei not enlarged, smooth contours, NC ratio OK. Not HSIL. • A Endocervical cells • Small round and regular nuclei. Compare to Ques #1. • E Reactive • See the trichomonas organism! • D LSIL • Koilocytes! • D LSIL • Koilocytes! • B Parakeratosis • Sometimes associated with dysplasia • D HSV • Herpes Simplex Viral changes in Nucleus • D Adenocarcinoma • Crowded overlapping nuclei with prominent nucleoli. No “feathering” so not Adeno in situ (AIS) • E HSIL • High NC ratio, irregular nuclei. This actually turned out to be a SCCA on biopsy. • A Reactive • No dysplasia, just some squamous cells with neutrophils.