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Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat fa

Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve . Eileen M. Foecking, PhD; Keith N. Fargo, PhD; Lisa M. Coughlin, MD; James T. Kim, MD; Sam J. Marzo, MD; Kathryn J. Jones, PhD . Aim

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Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat fa

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  1. Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve Eileen M. Foecking, PhD; Keith N. Fargo, PhD; Lisa M. Coughlin, MD; James T. Kim, MD; Sam J. Marzo, MD; Kathryn J. Jones, PhD

  2. Aim • Test whether electrical stimulation (ES) adminis-tered immediately after crush injury further decreases time for complete recovery from facial paralysis. • Relevance • Peripheral nerve injuries lead to various conditions, including paresis or paralysis. • Daily ES to facial nerve proximal to injury affects early events in nerve regeneration process in rats by initiating axon sprout formation.

  3. Methods • Rats received unilateral facial nerve crush injury. • Electrode positioned on nerve proximal to injury. • Rats received 30 min of ES daily for: • 1 d (day of injury), 2 d, 4 d, 7 d, or daily until complete functional recovery. • Untreated animals received no ES. • Rats were observed daily for return of facial function.

  4. Results • One session of ES was as effective as daily stimulation at enhancing recovery of most functional parameters.

  5. Conclusions • Use of one 30 min session of ES should be studied as possible treatment strategy for human patients with paralysis as result of acute nerve injuries.

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