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TOPOIC:Bacterial,Viral and Mycotic Infections

TOPOIC:Bacterial,Viral and Mycotic Infections. Lectured by Yeong-Lei HUANG D.D.S.,M.S. School of Dentistry,Kaohsiung Medical University, Taiwan (Republic of China ). 一 .INTRODUCTION. A.The invasion of tissue by living micro-organisms;disease is produced by their subsequent multiplication.

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TOPOIC:Bacterial,Viral and Mycotic Infections

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  1. TOPOIC:Bacterial,Viral and Mycotic Infections Lectured by Yeong-Lei HUANG D.D.S.,M.S. School of Dentistry,Kaohsiung Medical University, Taiwan (Republic of China )

  2. 一.INTRODUCTION

  3. A.The invasion of tissue by living micro-organisms;disease is produced by their subsequent multiplication. .Most micro-organisms are harmless:only a few are pathogenic i.e. can cause disease. .Bacteria and viruses are the most common. .Fungi and other groups are less common.

  4. B.Routes of entry of infecting organisms 1.Through the skin or mucous membranes. 2.By ingestion 3.By inhalation

  5. C.Factors influencing the establishment of infection. 1.In the host (1)Physical barries; skin (2)Secretions; mucin (3)Chemical action; Lysozymes (saliva) , IgA, non-specific inhibitory substances

  6. C.Factors influencing the establishment of infection. 2.In the micro-organism • Invasive capacity: (1)Quantity of dose (2)Virulence; Capacity to resist phagocytosis Capacity to produce enzyme Capacity to produce toxins

  7. D.Factors influencing the course of infection 1.Inflammation 2.Phagocytosis 3.The immune response 4.Interferon production

  8. 二.CONTENTS

  9. Common oral manifestation of micro-organism infectious disease.A.Bacterial infectionB.Viral infectionC.Fungal infections

  10. A.Bacterial infection .ANUG .Acute cellulits .Pyogenic granuloma .Tuberculosis .Actinomycosis .Syphilis .Leprosy .Sarcoidosis

  11. B.Viral infection .Herpes simplex .Primary herpetic stomatitis .Secondary herpetic gingivostomatitis .Recurrent apthous stomatitis .Herpangina .Hand,foot and mouth disease

  12. B.Viral infection .Measles .Molluscum contagiosum .Condyloma acuminatum .Herpes zoster .Mumps .Cytomegalic inclusion disease .HIV disease arid AIDS

  13. C.Fungal infections 1.Deep fungal disease * Clinically, infection often mimic T.B .Histoplasmosis, Coccidioidomycosis, .Blastomycosis, Cryptococcosis 2.Opportunistic fungal infections .Phycomycosis .Candidiasis

  14. A.Bacterial infection .ANUG .Acute cellulits .Pyogenic granuloma .Syphilis .Tuberculosis .Actinomycosis .Leprosy .Sarcoidosis

  15. Acute necrotizing ulcerative gnigivitis (ANUG) 1.Pathogen - fusiform baccilus and spirochete (Borrelia vicentii) 2.Pathogenesis - synergistically multiply of two pathogen 3.Clinical features - painful hyperemia gingiva , and foul odor sharply punched-out erosion of the interdental papillae 4.Histopathology – surface ulcerative with thickened fibrous exudates , containing many polymorphonuclear leukocytes and macrophages

  16. Acute cellultis 1.Pathogen - streptococus pyogens , Bacteroid (anaerobes) 2.Pathogenesis - dental origin on the presence of unusually virulent bacteria *Ludwig’s angina : involvement of submaxillary & sublingual and backwards into the parapharyngeal space 3.Clinical features - . brawny hardness of involved area , fever and malaise .difficulty in breathing as a result of tongue being pushed upward and backward into the airway 4.Histopathology - spread of exudate is separating & destroyed muscle fibers,between which many neutrophils can be seen

  17. Pyogenic granuloma 1.Pathogen—non-specific infection 2.Clinical features—over exuberant connective tissue reaction, are typically red. The ulcerated lesion may become covered by yellow, fibrinous membrane. 3.Histopathology— lobular masses of hyperplasic granulation tissue, vast numbers of endothelium-lined vascular spaces and proliferation of fibroblasts and budding endothelial cells.

  18. Syphilis 1.Pathogen- Treponema pallidum 2.Pathogenesis-Fig 1. 3.Clinical features— *1st stage—Hard Chancre *2nd stage—Mucous patch *Tertiary stage—Gummatous inflammation

  19. Syphilis 4.Histopathology * Proliferation of endothelial cell within arteries * Plasma cells, along with lymphocytes and macrophages, are found in a perivascular distribution * Necrosis and great numbers of macrophages, resulting in a granulomatous lesion

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