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A2E Agenda:

A2E Agenda:. Enzyme Function Worksheet/Activity (In IB 3406) Brief Aquaporin Structure and Function Overview Lab Presentations Group Discussion of Aquaporin Readings Aquaporin Revisited.

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A2E Agenda:

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  1. A2E Agenda: • Enzyme Function Worksheet/Activity (In IB 3406) • Brief Aquaporin Structure and Function Overview • Lab Presentations • Group Discussion of Aquaporin Readings • Aquaporin Revisited Reminder: Bring a food sample tomorrow (soy, papaya, or corn are best) if you’d like to test it tomorrow!

  2. Comparing Your Models

  3. Comparing Your Models

  4. Biological Functions of Aquaporins: What do your kidneys do?!?

  5. Some Biological Functions of Aquaporins Mammals have two kidneys, each supplied with LOTS of blood flow; as a result, all blood is filtered ~every 30 minutes Our kidneys can excrete urine 4X as concentrated (1,200 mosm/L) as our blood! Image: The Biology Project

  6. Some Biological Functions of Aquaporins Functional Unit = the Nephron (single long tubule with a ball of capillaries Kidneys are compacted bundles of nephrons (~1.3 million) all draining, eventually, into the ureter Image: The Biology Project

  7. What does Antidiuretic Hormone (ADH) do? Note that Antidiuretic Hormone (ADH) is also known as vasopressin.

  8. So should the cells lining the collecting ducts in your kidneys become more or less permeable to water in response to ADH? How might they control this permeability?

  9. Revisiting Aquaporin: Use your understanding of protein structure to construct a model (drawing) of what a water channel in a cell membrane would look like, and how it would orient itself in a plasma membrane.

  10. Structure of Phenylalanine and Tryptophan

  11. Glycerol

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