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Funny Neuron regeneration

刘恋 2013.5.27. Funny Neuron regeneration. Outline. 1. What is neuron like?. 2. What is neuron damage?. 3. Why we cannot recover ourselves?. 4. Remaining questions. 5. Colorful world in our CNS. What is neuron damage. Spinal cord injury-- 2,0000 people per year in USA

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Funny Neuron regeneration

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  1. 刘恋 2013.5.27 Funny Neuron regeneration

  2. Outline 1 What is neuron like? 2 What is neuron damage? 3 Why we cannot recover ourselves? 4 Remaining questions 5

  3. Colorful world in our CNS

  4. What is neuron damage Spinal cord injury--2,0000 people per year in USA Stroke ---700,000 people per year in USA third most common cause of death in USA

  5. Why we cannot recover ourselveses ? What is the main barriers for neuron regeneration

  6. Main barriers for neuron regeneration

  7. After injury ……what happens?

  8. When the neuron is cut…

  9. In the (Peripheral neuron system)PNS…

  10. Nogo protein Martin E. SchwabNature Reviews Neuroscience  (December 2010)  Structure of nogo protein Postmetamorphic frogs

  11. Nogo protein Martin E. SchwabNature Reviews Neuroscience  (December 2010) 

  12. Intrinsic regeneration capacity How did neuron know…? ” I’m injured!!” • Different neuron response differently

  13. DRGs conditioning lesion paradigm Namiko Abe, Valeria Cavalli.Current Opinion in Neurobiology (June 2008)

  14. Lens injury promote RGCs regeneration

  15. Injury signal pathway Fang Sun, Zhigang He. Current Opinion in Neurobiology (August 2010)

  16. NLS systems • NLS=nuclear localization signal • [importins] • [RanGTP] • [JIP]=JNK-interacting protein

  17. MAPKs pathway MAKPKs mitogen-activated protein kinase family=(MAP) kinases [JNK] c-Jun N-terminal kinase [Erk] extracellular signal-regulated kinase Cargo that transport MAKPs vimentin: scaffolding protein for Erk 1 (steric hindrance) importin-activated Erk-vementin complex axonal vesicles: JNK

  18. Local activation & retrograde

  19. MAPKs pathway

  20. Erk & JNK ERK 2 JNK ERK2 & JNK

  21. Main Cytokines signal pathway IL-6 interleukin-6 LIF leukemia inhibitory factor CNTF cilliary neurotrophic factor

  22. STAT3 signal pathway Content 01 Content 02 Content 03 socs3 Fang Sun, Zhigang He. Current Opinion in Neurobiology (August 2010)

  23. mTOR signal pathway Content 02 Content 03 socs3 Fang Sun, Zhigang He. Current Opinion in Neurobiology (August 2010)

  24. Injury signal pathway Fang Sun, Zhigang He. Current Opinion in Neurobiology (August 2010) • summary

  25. Remaining question Why ??

  26. Thank You !

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