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Matrix Metalloproteins (MMPs)

Matrix Metalloproteins (MMPs) . How Zn2+ is involved in the catalytic domain and how it can be inhibited. What are MMP’s?. Pro-domain catalytic domain . Similarities/differences between catalytic & pro domains of MMPs. How are MMP’s involved in disease?. Mechanism.

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Matrix Metalloproteins (MMPs)

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  1. Matrix Metalloproteins (MMPs) How Zn2+ is involved in the catalytic domain and how it can be inhibited.

  2. What are MMP’s? • Pro-domain • catalytic domain Similarities/differences between catalytic & pro domains of MMPs

  3. How are MMP’s involved in disease?

  4. Mechanism

  5. How was this structure discovered? • XANES (X-Ray Absorption Near-edge Structure) • Zn2+ coordination • Different pH • Mutating active site residues These people don’t consider the enzyme in its inactive state, ie. cysteine switch.

  6. How is the active site inhibited? • Understanding the catalytic domain leads to an understanding of how it is inhibited. • And here’s how… • How the Zn coordination is altered ***Focus on techniques used small molecule screening for development of drugs TIMPs

  7. Future Endeavours • Why does deletion of different MMPs cause a variety of phenotypic mutations?

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