A follow up study of mild cognitive impairment in Beijing ----finding from 10/66 study

1. A follow up study of mild cognitive impairment in Beijing----finding from 10/66 study Zhaorui Liu, Chuanjun Zhuo, Yueqin Huang, Shuran Li, Institute of Mental Health, Peking University Martin Prince Institute of Psychiatry, King’s College London

2. Background • A new dementia case every 7 seconds • Cost of dementia: 1% of Global GDP • Early intervention: crucial • MCI - early dementia?

3. Background • Incidence study on MCI: (65+) Ravaglia ：4-year cumulative incidence 22.6% Larrieu ：99/1000 person year Solfrizzi ：incidence: 2.76% Zhu：5-year cumulative incidence:8.0% • Transition MCI-dementia : 10%～15% every year Normal-dementia: 1.6%～3%every year

4. Objectives • To describe the incidence of mild cognitive impairment (MCI) • To analyze the transition from MCI to dementia • To explore risk factors of MCI incidence and the transition

5. Design • Part of 10/66 study in China • Two settings: Rural-Daxing, Urban-Xicheng • Baseline: 2004 • Follow-up study: 2009 • 2012 older persons

6. Subjects • Incidence part: 1859 older persons with normal cognitive function elderly at the baseline • Transition part: 166 MCI patients at the baseline

7. Measurements • Cognitive Test: CSID • Geriatric Mental State-B3 version • Informant Interview Questionnaire • Background Socio- demographic and Risk factor Questionnaire • Self-report chronic diseases, physical examination

8. Diagnose • MCI were diagnosed according to the general MCI criteria developed by Stockholm international conference. • Cognitive impairment, not dementia • Self-report or informant-report cognitive impairment • independent activities of daily life, complex task slightly affected

9. Flow chart • Incidence part Missing 190 Dementia 137 New MCI case 193 Baseline 2162 Normal cognitive function 1859 MCI 166 Died 428

10. Results • Incidence of MCI 5-year cumulative incidence 10.38% Average annual incidence rate was 2.17% (95%CI: 1.76~2.30%) Age groups Male Female

11. Results • Incidence of MCI 5-year cumulative incidence 10.38%Average annual incidence rate was 2.17% (95%CI: 1.76~2.30%) Urban Rural No-education Primary Secondary Tertiary

12. Results • Protective factors of MCI • having spouse • physical exercise • Cox regression • Risk factors of MCI • older age • living in a rural area • lower education • history of stroke • history of diabetes • larger Waist Hip Ratio

13. Flow chart • Transition part Missing 7 Died 54 Dementia 74 Baseline MCI 166 found 159 Normal 10

14. Results • MCI to dementia 5-year cumulative transition rate 43.97%, Average annual transition rate was 10.94%（95%CI: 7.30-12.18%） • Protective factors of the transition • having spouse • physical exercise • Risk factors of the transition • older age • living in a rural area • lower education • history of stroke • hypertension • heart disease

15. Contribution • Similar risk factors are found for the MCI occurrence and conversion as well. • This study provides a foundation for future prevention and intervention of MCI, which are of significant social and clinical value.

16. Thank you Corresponding to Prof. Yueqin HUANG huangyq@bjmu.edu.cn