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Muscle Physiology

Muscle Physiology. Summer Prematriculation Program Summer 2004 Rahul Dave’. Rdave2@uic.edu (312) 996-7610 Rm 206 CMW. Muscles act in many organ systems. Muscles need a signal to contract. Muscle Anatomy. Motor Unit. Main Nerve. Nerve branch. Muscle. Skeletal Muscle. Smooth Muscle.

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Muscle Physiology

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  1. Muscle Physiology Summer Prematriculation Program Summer 2004 Rahul Dave’ Rdave2@uic.edu (312) 996-7610 Rm 206 CMW

  2. Muscles act in many organ systems

  3. Muscles need a signal to contract

  4. Muscle Anatomy

  5. MotorUnit Main Nerve Nerve branch Muscle

  6. SkeletalMuscle

  7. Smooth Muscle

  8. Cardiac Muscle 1

  9. Cardiac Muscle 2 Intercalated Disc

  10. 3 Fiber Types

  11. Sarcomere Structure M-line Z-disc H-zone I-band I-band A-band

  12. Sliding Filament Theory

  13. Other Muscle Proteins Brown Tropomyosin Yellow Troponins Blue Actin Black Myosin Head Bind Site Pink Myosin

  14. Smooth Muscle Structure

  15. Muscle Structure • Describe the hierarchy of organization in muscle • Distinguish smooth, skeletal and cardiac muscle based on histology • Understand and rationalize the differences between fiber types • Know the skeletal muscle sarcomere structure cold.

  16. Nerve-MuscleInterface

  17. Excitation-Contraction Coupling

  18. Cross Bridge Cycle

  19. Smooth MuscleNerve-Muscle Interface

  20. E-C Coupling (Smooth) Neurotransmitter G IP3 PIP2 Ca2+ SR

  21. Crossbridge Cycle (Smooth)

  22. Muscle Contraction • Know each step in transmission across the neuromuscular junction • Know each step in E-C Coupling for striated muscle • Know each step in the cross-bridge cycle for striated muscle • Know the differences between smooth and striated (skeletal + cardiac) muscle

  23. Preload and Afterload Preload The force (load) a muscle exerts prior to contraction. Pre-contraction Afterload Force muscle exerts during contraction. After [the start of] contraction Demonstration

  24. Frank-Starling Law

  25. Force-Velocity Curve

  26. Exercise Physiology These are all adaptations • Learning new motor patterns • Strength exercises: muscle hypertrophy • Endurance exercises: changes in muscle metabolism

  27. Muscle Diseases Metabolism • Lactic Acidosis • Glycogen Storage Diseases Muscle Function • Dilated Cardiomyopathy • Muscular Dystrophy • Malignant Hyperthermia • Neurologic • Hirschsprung’s disease • Myesthenia Gravis • Multiple Sclerosis • Parkinson’s Disease • Polio

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