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Neurofarmacología ; Analgésicos (2da parte) Opioides I

Neurofarmacología ; Analgésicos (2da parte) Opioides I. Dr . José Renán Pérez P. 14.10.12. Introducción. Opiode : Compuesto relacionado con el opio Papaver somniferum Opiáceo: Derivados del opio (codeína, tabaína ) Endorfina: Péptidos opioides endógenos.

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Neurofarmacología ; Analgésicos (2da parte) Opioides I

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  1. Neurofarmacología;Analgésicos (2da parte)Opioides I Dr. José Renán Pérez P. 14.10.12

  2. Introducción • Opiode: Compuesto relacionado con el opio • Papaversomniferum • Opiáceo: Derivados del opio (codeína, tabaína) • Endorfina: Péptidos opioides endógenos. Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  3. Historia • Teofrasto III Ac • 1680 Sydenham • 1810 Aislamiento de la morfina • 1970 Naloxona • 1975 Encefalina • 1976 receptores μ,δ,κ • 1994 Receptors FQ Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  4. Opiodes endógenos

  5. POMC proencefalina Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  6. Receptores κ μ δ

  7. Acoplamiento • Desensibilización • Tolerancia • Aguda • Crónica Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  8. Efectos clínicos Recompensa μ Analgesia Termoregulación • Localización: • Talámica • Sustancia gris PA • Rafé • Hasta Posterior • GRD Miosis Neuroendócrinos Crisis epileptiformes Respiración Tos Eméticos κ Antianalgesia Cardiovascular Gastrointestinal Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  9. Morfina Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  10. Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  11. Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  12. Levorfanol • Agonista de receptores de morfina • Dextrorfano (isómero-D) InhibeNMDAr • Famarmacocinética similar a morfina • t1/2 of 12-16 h • Mejortolerado • Nalbufina* • Butorfanol* Yaksh TL, Wallace MS. Opioids, Analgesia, and Pain Management. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman & Gilman'sThePharmacologicalBasis of Therapeutics. 12th ed. New York: McGraw-Hill; 2011

  13. Meperidina • Agonistas de receptoresμ • Efecto principal en SNC y elementosneurales en GI. • Analgesia. Congéneres: Trastornos GI

  14. Fentanilo

  15. Tramadol • Análogo sintético de Codeína • Agonista débil μ • Inhibidor de recaptura de Na y 5HT

  16. Agonistas paciales • Agonistas μ y κ • Pentazocina • Nalbufina • Butorfanol • Buprenorfina

  17. Fin de 2da parte

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