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Managing Multiple Sclerosis with Apitherapy

This study evaluates the efficacy of bee venom acupuncture as an alternative therapy for the long-term treatment of rheumatoid arthritis (RA). The study compares the effects of bee venom acupuncture with pharmacotherapy in RA patients. Forty patients with RA are randomly assigned to receive bee sting therapy or conventional drug therapy. Various clinical parameters and serum cytokine levels are assessed before and after treatment. This study aims to explore the potential benefits of apitherapy in the management of multiple sclerosis.

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Managing Multiple Sclerosis with Apitherapy

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  1. MANAGEMENT OF MULTIPLE SCLEROSIS: APITHERAPY MANAGEMENT OF MULTIPLE SCLEROSIS: APITHERAPY IN THE NAME OF GOD IN THE NAME OF GOD Influence of Bee Venom on Rheumatoid Arthritis Patients Ahmed G. Hegazi, Maha M. Saber, Eitedal Daoud, Aliaa al Gendy and Eman Abd el-Rahman National Research Centre, Dokki, Giza, Egypt

  2. What Apiacupuncture can do for arthritis?

  3. Honeybee Stinger

  4. The exuded sting with a small drop of venom on it

  5. The sting and its poison gland attached

  6. Close-up of the sting showing the barbs, which allows the sting to anchor inside the victim's flesh, much like the barb on a fishing hook.

  7. A worker bee trying to get away after stinging. The sting has barbs preventing the sting to be pulled out, part of her digestive system is seen dragging behind her

  8. Symptoms •Bee venom causes local pain, redness, and swelling in people who are not allergic.

  9. Lewis,FS, Smith, LJ. What’s eating you? Bees, part 1. Cutis 2007;79:439-44

  10. Two minutes after being stung. The sting is removed to show the site of sting entry

  11. The site of a sting injury after 24 hours. Light red and swelling is seen, a small scar tissue is forming at the site of sting entry.

  12. Urticaria (hives) on a person, who is having a systematic reaction to a bee sting. This can be a prelude to an anaphylactic response, which can be fatal if not treated immediately.

  13. VENOM Composition a mixture of proteins & peptides melittin phospholipase A hyaluronidase acid phosphatase histamine 50% dry wt 12% dry wt <3% dry wt. <1% dry wt. <1% dry wt.

  14. VENOM Melittin lysis of blood & mast cells  release of histamine & serotonin from mast cells  depression of blood pressure & respiration. Phospholipase A cell lysis  pain  toxicity synergistic with melittin

  15. VENOM Hyaluronidase hydrolyzes connective tissue the spreading factor Histamine itching & pain Acid phosphatase involved in allergic reaction

  16. Bee Venom: •Applications in the field of medicine •Basic protein research using venom

  17. The aim of this study is to evaluate the efficacy of bee venom acupuncture as alternative medicine therapy for the long term treatment of rheumatoid arthritis (RA).

  18. Materials and Methods This study is a randomized, controlled clinical trial with two parallel arms. The study intend to compare the effects of BVA and with pharmacotherapy only in patients with RA.

  19. Materials and Methods Forty patients with Rheumatoid arthritis disease are allocated to group of patients with RA are treated with BVA (bee sting) therapy While other group of patient with Rheumatoid arthritis disease on convention drug therapy.

  20. Forty patients known to be with RA  ages ranged years, with a mean of 38.7 ± 4.8. 2 between 26-71

  21. All cases were subjected to complete clinical and history Examination to confirm the diagnosis.

  22. Materials and Methods Tender joint count, swollen joint count, morning stiffness, visal analog scal (VAS), health assessment Q,

  23. Materials and Methods ESR, CRP, Tumor Necrosis Factor (TNF), Interleukin 1(IL1) Interleukin 6,(IL6), Nuclear Factor and Kappa B (NF-KB). All these parameters will be assessed before and after treatment.

  24. All cases were under their regular treatment either by corticosteroids  These cases were divided into two main groups, each group consists of 20 cases

  25. Group I received treated with bee acupuncture 3 times weekly, for 12 months, started gradually by one sting then gradually increase up to 25 stings per session, in addition to their medical treatment

  26. Group I received treated with bee acupuncture 3 times weekly, for 12 months, started gradually by one sting then gradually increase up to 25 stings per session, in addition to their medical treatment

  27. LI 4

  28. LI11

  29. SP6

  30. ST36

  31. GV14

  32. ST 35

  33. GB 34

  34. LIV3

  35. Group II Group II remains on their ordinary medical treatment only.

  36. Serum samples were obtained from patients with clinically definite RA for estimation of serum levels of immunoglobulin E (Hirano et al., 1989) using commercially available ELISA kits according to the manufacturers' directions.

  37. Serum cytokine levels interleukin (IL) 1β, IL-6, NFkβ concentration tumor necrosis factor alpha (TNFα)

  38. All these investigations were done at the beginning of the study and by the end of 12 months of bee sting sessions

  39. Age

  40. Duration

  41. Weight, Height and BMI

  42. Visal analog scale (VAS)

  43. Tender joint count

  44. Swollen joint count

  45. ESR

  46. Disease activity score in 28 joints

  47. Dressing

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