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The Biotechnology Center of Excellence Bringing Biotech from the Bench to the K-12 Classroom

The Biotechnology Center of Excellence Bringing Biotech from the Bench to the K-12 Classroom. Event : Regenerative Medicine Webinar Date: May 22, 2014, 4pm & 7pm CST Location: Lindblom Math & Science Academy. Hortense Brice, Presenter hebrice@gmail.com

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The Biotechnology Center of Excellence Bringing Biotech from the Bench to the K-12 Classroom

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  1. The Biotechnology Center of Excellence Bringing Biotech from the Bench to the K-12 Classroom Event: Regenerative Medicine Webinar Date: May 22, 2014, 4pm & 7pm CST Location: Lindblom Math & Science Academy

  2. Hortense Brice, Presenter hebrice@gmail.com Dr. Emily Ferrin, Facilitator emily.ferrin@northwestern.edu BCoE.net osep.northwestern.edu

  3. Webinar Objectives • As a Result of Webinar Participation, You Will: • Realize the Need for Regenerative Medicine Practices and Procedures • Identify the Tools and Technologies of Regenerative Medicine • Understand the Challenges, Promise and Potential of Regenerative Medicine • Identify the Potential Benefits of Regenerative Medicine to America’s Costly Health Care System

  4. “Body Builders”: The Emerging Science of Regenerative Medicine

  5. The Beginning……… Charles Vacanti & Robert Langer (1997)

  6. Characterizing Regenerative Medicine • Regenerative medicine is a broad definition for innovative medical therapies that will enable the body to repair, replace, restore and regenerate damaged or diseased cells, tissues and organs. (Mayo Clinic) • Science Merges with Technology to Achieve Self-Healing • Regenerative medicine uses procedures to repair or replace damaged or diseased tissues and organs—Many traditional therapies only treat symptoms. 3. Tools and Procedures (Biofabrication or Additive Manufacturing) of Regenerative Medicine • Tissue Engineering: Tissue Repair/Replacement and Lab Grown Organs • Technologies • Stem cells • Natural and Synthetic Scaffolds • 3-D Printing and Chip Technologies 4. Highly Interdisciplinary Field where Biology and Chemistry meet: • Engineering • Material Science

  7. Areas of Regenerative Medicine • Artificial Organs: Medical Devices (Lab Grown Bladder) 2.Tissue Engineering & Biomaterials Scaffolds

  8. Areas of Regenerative Medicine 3. Cellular Therapies • Use of Stem Cells (From Patient) • Development of Regenerative Medicine Treatments. • Enhance Regeneration of Tissues and Organs. • Clinical Trials • Many Currently in Progress. • NIH and Private Organizations.

  9. Regenerative Medicine Procedures/Protocols Engineer Scaffolds Spaghetti Highways Hydrogel Ear Scaffold

  10. Regenerative Medicine Procedures/Protocol Seed Scaffold With Stem Cells

  11. Regenerative Medicine Procedures/Protocol • Incubate Seeded Scaffold in Bioreactor • Transplant into An Animal Model

  12. Regenerative Medicine And PRP Therapy • PRP: Platelet Rich Plasma Therapy • Concentrate Platelets from Patients Blood Sample • Platelets Contain Cytokines and Growth Factors • PRP Accelerates Healing and Reduces Pain • Bill Nye “The Science Guy” and PRP Therapy

  13. Regenerative Medicine Pioneer Wake Forest Institute for Regenerative Medicine (WFIRM) Dr. Anthony Atala • First to Engineer/Transplant Lab-Grown Organ into a Human • Transplant was Successful • Currently Developing Organ on a Chip Program

  14. Regenerative Medicine Pioneer Dr. Paolo Macchiarini (Karolinska Institute) • 2008: Implanted World’s First Donor Trachea • Recipient: Claudio Castillo • Survived Procedure—Now Has Normal Respiratory • Function

  15. Regenerative Medicine Pioneer McGowan Institute of Regenerative Medicine (University of Pittsburg) Dr. Stephen Badylak • Removed Cells from Pig • Bladder Extra Cellular Matrix (ECM) • Dried: Forms “Pixie-Dust” • Re-grows Severed Digits and • New Muscle Tissue

  16. Regenerative Medicine Pioneer AFIRM: Armed Forces Institute Of Regenerative Medicine. • Treatment Procedures for Severely Wounded Soldiers • Funded and Managed by US Army • Partnership with Wake Forest Institute for Regenerative • Medicine

  17. Regenerative Medicine Innovator Dr. Geraldine Hamilton (Wyss Institute) Organ on a Chip Technology (Drug Testing Tool)

  18. Regenerative Medicine Innovator Jordan Miller (Rice University) • Uses 3-D Print Technology • Engineers Blood Vessels Using Sugar

  19. Regenerative Medicine Innovator Ramille N. Shah, PhD (Northwestern University) • Leader in Field of 3D-Printable Materials • Engineers new 3D-Inks • Creates Porous Scaffolds • Technique: Additive Manufacturing (Nanofiber Scaffold For Cartilage Regeneration)

  20. Regenerative Medicine Challenges • Design of Biomaterials that Function in the Body • Getting Enough Cells and Cell Types for Engineering Tissues and Organs • Vascularity: Engineering Blood Vessels that Supply Nutrients, Oxygen and Signals to Bioengineered Tissues and Organs • Cost of Tissue and Organ Development Procedures

  21. Organ Decellularization Approach Dr. Harald Ott http://www.youtube.com/watch?v=5wfdhB_VyJw

  22. Challenge To Regenerative Medicine Bioengineering of Organs

  23. Potential of Regenerative Medicine Chip Technology • Reduces Need for Animal Testing • 3-D Printed Organs on Chips Used to Test Vaccines

  24. 3-D Elastic Membrane Fits Heart’s Epicardium Promise of Regenerative Medicine 3-D Printer Creates Heart Membrane

  25. The Business of Regenerative Medicine Organovo • 3-D Bioprinting Company • Started A Collaboration with NIH (January 2014) • Goal: Bioprinting of 3D Living Tissues • Eliminate Challenges to New Therapy Development • Animal Models: Poor Predictors of Drug Efficacy and Toxicity

  26. The Business of Regenerative Medicine Tengion • A Biotechnology Company • Company Platform for Engineering Tissues/Organs • Organ Regeneration Process • Doctors send Tissue Sample from Diseased or Failing Organ to Tengion • Tengion Selects and Multiplies Healthy Cells • Place Cells on an Organ-Shaped Scaffold • Result: A Neo-Organ for Transplant

  27. Futuristic! Stem Cells + Organ Scaffold + 3D Printer = Libraries of Replacement Organs?

  28. Regenerative Medicine Summary • Regenerative Medicine Approaches • Use of Patients Stem Cells • 3-D Bioprinting of Tissues and Organs • Organ Decellularization • PRP: Plasma Rich Platelet Therapy • Human Treatment • Veterinary Medicine Therapy

  29. Regenerative Medicine And Healthcare • New Era in Medicine: Move from Treatment to Cures (Self-Healing) • Eliminate Organ Transplant Shortage • Reduce Health Care Costs • Now A Medical and Commercial Reality • Over 60, 000 Stem Cell Transplants Worldwide • 2012: Cell Therapies Generated More Than $900 Million

  30. Thank you! osep.northwestern.edu hebrice@gmail.com emily.ferrin@northwestern.edu

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