1 / 9

Agonists and Antagonists

APC. antagonist peptide. agonist peptide. T cell. stimulation suppressed. stimulation. Agonists and Antagonists. APC. agonist peptide. T cell. +ve. -ve. Minimal Model. 3 species model:. [X]+[Z]=M=const. Irreversibility Branching Feedback with distinct time scale.

morey
Download Presentation

Agonists and Antagonists

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. APC antagonist peptide agonist peptide T cell stimulation suppressed stimulation Agonists and Antagonists APC agonist peptide T cell

  2. +ve -ve Minimal Model 3 species model: [X]+[Z]=M=const • Irreversibility • Branching • Feedback with distinct • time scale Minimal Model for cell signaling with positive and negative feedbacks

  3. +ve -ve Minimal Model Mean field Analysis 3 species model: • Irreversibility • Branching • Feedback with distinct • time scale Rate equations : [X]+[Z]=M=const number conservation : initial values (t=0) : Minimal Model for cell signaling with positive and negative feedbacks

  4. +ve -ve Minimal Model Mean field Analysis 3 species model: • Irreversibility • Branching • Feedback with distinct • time scale Solutions: [X]+[Z]=M=const stability: no un-stable mode Minimal Model for cell signaling with positive and negative feedbacks

  5. +ve -ve Minimal Model Mean field Analysis 3 species model: • Irreversibility • Branching • Feedback with distinct • time scale [X]+[Z]=M=const Minimal Model for cell signaling with positive and negative feedbacks

  6. Master Equation: Generating function: Solution: Effects of Stochastic Fluctuations 3 species model: Exactly Solvable

  7. large N large k3 Fixed k3/N purely stochastic origin of bimodality Effects of Stochastic Fluctuations 3 species model: Exactly Solvable Stochastic Analysis Mean field Master Equation: small N small k3 Fixed k3/N [X]+[Z]=M=const Generating function: Solution:

  8. X f ~ 1/(k2nxnynz) rate 1 P() Z rate 2 d ~ 1/(k3ny) Z d f Effects of Stochastic Fluctuations 3 species model: Exactly Solvable Origin of Stochastic Bistability (activation) Master Equation: [X]+[Z]=M=const (de-activation) Generating function: Solution:

  9. agonist antagonist No signal Signaling product Cell Decision Mediated by Stochastic Fluctuations M. Artyomov, JD, M. Kardar, A. Chakraborty PNAS (2007)

More Related