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Agonists and Antagonists

Agonists and Antagonists. Agonists interact with receptors to produce the same cellular effect that is seen with the naturally occurring binding chemicals (ligands) eg salbutamol (eg Ventolin) – agonist at beta 2 receptors; stimulation results in smooth muscle relaxation

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Agonists and Antagonists

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  1. Agonists and Antagonists • Agonists interact with receptors to produce the same cellular effect that is seen with the naturally occurring binding chemicals (ligands) • eg salbutamol (eg Ventolin) – agonist at beta2 receptors; stimulation results in smooth muscle relaxation • Antagonists interact with receptors and block the effects of the naturally occurring ligands • eg ranitidine (eg Zantac) – antagonist at histamine H2 receptors; blockade reduces acid secretion in the stomach

  2. Problems with relying on acid secretion as sole mechanism of peptic ulcer healing • Treatment has to be continuous. After cessation of therapy acid secretion quickly rises and ulcer recurrence rates are high (70% in 12 months for duodenal ulcers) • Inhibition of acid secretion does not eradicate H Pylori • However acid secretionis valuable in the healing and prevention of ulcers due to NSAIDs

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