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Vanderbilt University Department of Biomedical Engineering

Vanderbilt University Department of Biomedical Engineering. Device for Quantification of Re-Innervation of a Laryngeal Muscle. Advisor : Dr. David Zealear Designers : Thomas Thomasson and Nirav Patel. February 25, 2000. Background.

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Vanderbilt University Department of Biomedical Engineering

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  1. Vanderbilt UniversityDepartment of Biomedical Engineering Device for Quantification of Re-Innervation of a Laryngeal Muscle Advisor: Dr. David Zealear Designers: Thomas Thomasson and Nirav Patel February 25, 2000

  2. Background • What ?- Development of a design and technique for the quantitative measurement of a re-innervated laryngeal muscle • Why ?- To increase quality of life for patients suffering from denervated muscular system • Who ? - Patients that have lost muscle control through paralysis of laryngeal muscles (estimates of 15,000/yr)

  3. Background Cont... • How ?- Recording EMG readings passes through the developed circuitry while tactile stimulation of the nerves is performed • Analysis? -Integrated recordings over time show degree of re-innervation and muscle fiber reconstruction counts

  4. Objectives • To Measure electromyographical potentials using electrodes. • To establish an index of synkinesis that compares pathological nerve re-innervation to normal nerve alignment • To use index of synkinesis to determine severity of pathology. • To measure muscle fiber bundles that have been re-innervated (secondary measurement of paralysis severity)

  5. Circuit • Bandpass Filter • Removes DC noise and high frequency AC noise • Cutoff frequency of 1 Hz and 1000 Hz • Rectifier • Returns absolute value of input • Integrator • Calculates area under input curve • Peak Detector • Holds maximum value from the integrator

  6. High Pass Filter • Cutoff frequency of 100 Hz • Removes DC Voltage entering Circuit

  7. Low Pass Filter • Cutoff frequency of 100K Hz

  8. Full Wave Precision Rectifier • Positive Wave Rectifier: Vout = Vin • Diodes Act Linearly in Feedback Loop

  9. Integrator • Integrates the Rectified Wave Over Time by the equation: Vout = -1/(Rf Cf )  Vin dt

  10. Peak Detector • Holds the Maximum Positive Output from the Integrator

  11. Finish Debugging Integrator After Consulting Dr. Galloway and Dr. Massengill A digital output meter will be bought to be added to the circuitry as a final output source Development of index of synkinesis through statistical analysis upon completion of canine experiments DesignSafe has been begun; consultation with Sebastien Daleyden and Vincent Goussen on Monday Current Work

  12. Future Work • Hard-wiring will begin after circuit passes initial test • Calculations for timing sequences of tactile stimulation will be discussed with Dr. Zealear • Testing of circuit with control canine experiments

  13. References • Farmer, Stephen and Douglass Hay. The Airway Epithelium. Vol 55. Marcel Decker, New York: 1991. • Dworkin, James and Robert Meleca. Vocal Pathologies. Singular Publishing, San Diego: 1997. • Michaels, L. Pathology of the Larynx. Springer-Verlag, Great Britain: 1984.

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