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Specialist for Enzymes and Inflammation

Specialist for Enzymes and Inflammation. Welcome!. Synonyms: Systemic Enzyme Support = SET Oral Enzyme Support. Systemic Enzyme Support. The founder of SET - History. Prof. Max Wolf (1885 – 1976). Physician und Scientist from Vienna

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Specialist for Enzymes and Inflammation

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  1. Specialist for Enzymes and Inflammation

  2. Welcome! • Synonyms: • Systemic Enzyme Support = SET • Oral Enzyme Support

  3. Systemic Enzyme Support The founder of SET - History Prof. Max Wolf (1885 – 1976) • Physician und Scientist from Vienna • Developed Enzyme Therapy together with HelenBenitez in New York • (Wolf-Benitez-Enzyme-Therapy) Prof. Max Wolf and Karl Ransberger

  4. An established naturopathic treatment The position of SES within naturopathy Phyto-Therapy Enzyme-Therapy PhysicalTherapy Homeo-pathy Substitution at pancreatic insufficiency Systemic Enzyme Support

  5. Enzyme classes

  6. Which type of enzymes in SES? Proteases are macromolecular proteins • Chain of amino acids • The three-dimensional structure is necessary for their biological effectiveness Units for proteins: 20.000 - 30.000 m.w. Model of Chymotrypsin Hydrolases

  7. Enzymes used by Mucos Naturally, high effective substances Papainfrom latex of unriped fruits of papaya (Carica papaya) Bromelainfrom pineapple (Ananas comosus) • Enzymes from Pancreas:(high purification technology): • TrypsinandChymotrypsin • Pankreatin(mixture of Trypsin and Chymotrypsin) additional active substance: Rutosid, a bioflavonoide from the flower bud of japanese pagoda tree

  8. Absorption Absorption of enzymes is a proven fact Conditions for effective absorption: • Taking beyond of mealtimes (45 min before or 1,5 hours after) • Gastric acid resistant coating • Dissolving in small intestine

  9. Average serum concentrations of Bromelain after oral dose of 4 x 4 respectively 4 x 8 tablets Wobenzym® N per day(mean value from 20 test subjects) Dosages and serum concentration

  10. AUC of Bromelain after oral dose of 4 tabletsWobenzym® N (2 subjects) Individuality

  11. What happens after absorption? Linkage to Antiproteases Proteases combine with Antiproteases • Alpha-2-Macroglobulin (2-MG) • Alpha-1-Antitrypsin Results in: • Loss of antigenetic potential of Proteases • while maintaining the biological activity of proteases

  12. The key role of 2-Macroglobulin One 2-macroglobulin combines two enzyme molecules 2-MG place where the cytokines combines

  13. Different Cytokine pools IL-4, IL-5, IL-10, TGF-ß suppress the immune system INF-γ, TNF-α, IL-2, IL-6, IL-12 stimulate the immune system Th2 Th1 Cytokine-imbalance leads to immune system problems

  14. Effect Bro-melain Papain Trypsin Chymo- trypsin Supports Circulatory Function +++ + ++ + Haemodilution + - +++ +++ Reduction of circulating immuncomplexes (CIC) ++ +++ - + +++ Regulation of Immune Function ++ ++ +++ Balancing of Cytokines ++ ++ ++ ++ Enzyme combinations? Different enzymes – different effects! Source: Modified from,Klaschka, Neue Perspektiven der Tumortherapie, Forum Medizin Verlag, 1996

  15. Wobenzym® N Pankreatin 100 mg Trypsin 24 mg Chymotrypsin 1 mg Bromelain 45 mg Papain 60 mg Rutosid 3 H2O 50mg 940 F.I.P.-Units

  16. Dosage 1. week: 3 x 5 tablets per day beginning 2. week: 3 x 3 tablets per day Wobenzym® N

  17. Please contact us by email: mis@online.ms Ruth Miller M.D. or Winfried Miller M.D. / D.V.M If you have any questions ….

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