1 / 34

Nutrients

Nutrients. Carbohydrates Lipids Proteins Vitamins Minerals Water. Food Pyramid. Digestion of Carbohydrates. a -amylase. b -amylase. Three enzymes required a -amylase b -amylase Debranching Enzyme. Debranching Enzyme. Digestion of Carbohydrates. debranching enzyme.

susan
Download Presentation

Nutrients

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Nutrients • Carbohydrates • Lipids • Proteins • Vitamins • Minerals • Water Food Pyramid

  2. Digestion of Carbohydrates a-amylase b-amylase • Three enzymes required a-amylase b-amylase Debranching Enzyme Debranching Enzyme

  3. Digestion of Carbohydrates debranching enzyme

  4. Digestion of Fats • Require Bile Salts for Solubilization • Require Lipases to Break Down • Transported via Chylomicrons

  5. Transport of Fats

  6. Digestion of Proteins • Proteases hydrolyze the peptide bond • Different proteases cleave proteins at specific positions Chymotrypsin Cleavage Sites

  7. Specificity of Proteases • Chymotrpsin • Cleaves after large nonpolar residues • Tyrpsin • Cleaves after Arg and Lys residues • Elastase • Cleaves after small nonpolar residues

  8. Regulation of Proteases and Lipases: Proenzymes Enzyme Cascades – 1  10  1000  10000

  9. Essential Fatty Acids and Amino Acids • Essential Fatty Acids • Linoleic (18C, 2 Double Bonds) • Linolenic (18C, 3 Double Bonds)

  10. Vitamins • Required for Normal Growth and Function • Organic Molecules • Synthetically Complex • Precursors to Enzyme Cofactors • Grouped as Water-soluble or Fat-soluble

  11. Water vs. Fat-soluble Vitamins

  12. Water-Soluble Vitamins

  13. Fat-Soluble Vitamins

  14. Vitamin C

  15. Vitamin C Deficiency Leads to Scurvy

  16. Collagen Collagen

  17. Vitamin C

  18. Vitamin K is Required for Clot Formation

  19. Case Study of Folate Deficiency and Biochemical Considerations http://www.hscbklyn.edu/SUNY/Biochem/ALCOHOL/alcohol_case1.html Background on Folate and B12 Metabolism. http://www.hscbklyn.edu/SUNY/Biochem/ALCOHOL/alcohol_folate_bkgd.html

  20. Folic Acid is reduced to THF Enzyme cofactor: thymidylate synthase

  21. Folic Acid is reduced to THF Enzyme cofactor: thymidylate synthase

  22. Folic Acid is reduced to THF Enzyme cofactor: thymidylate synthase

  23. Uracil (U) Thymine (T) Folic Acid is Converted to THF thymidylate synthase: dUMP + methylene-THF --- > dTMP + dihydrofolate (DHF)

  24. Uracil (U) Folic Acid is Converted to THF thymidylate synthase: dUMP + methylene-THF --- > dTMP + dihydrofolate (DHF) Thymine (T)

  25. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity http://www.rcsb.org/pdb/cgi/explore.cgi?job=graphics&pdbId=2KCE&page=99&pid=286001115140247

  26. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

  27. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

  28. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

  29. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

  30. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

  31. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

  32. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

  33. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

  34. Binding Of The Anticancer Drug Zd1694 To E. Coli Thymidylate Synthase: Assessing Specificity and Affinity

More Related