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Medicinal Mushrooms

Medicinal Mushrooms. Fact, Fiction andFolklore. What We Know…. Today, there are over 270 identified fungal species with known therapeutic properties. (NAMA.org). Medicinal Mushrooms. What They Can Do…

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Medicinal Mushrooms

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  1. Medicinal Mushrooms Fact, Fiction andFolklore

  2. What We Know… • Today, there are over 270 identified fungal species with known therapeutic properties. (NAMA.org)

  3. Medicinal Mushrooms What They Can Do… Nematicidal(kill nematodes) Immunopotentiating, Anti-tumor, Immunomodulating,, Antibacterial, Antifungal, Anti-hypertensive, Anti-inflammatory, Anti-oxidant, Anti-protozoal, Anti-viral, cholesterol-lowering, diuretic (help expel excess water), hepatoprotective(liver), immunosuppressive, molluscicidal(kills snails and slugs), Nerve tonic, and as adjuncts to cancer chemotherapy and radiation. (from NAMA.org)…to say nothing of certain species ability to offer a different perception on the world and our place in it…

  4. Anti-Bacterial • The mushroom is also uniquely proficient at expelling undesirable chemicals and contaminants absorbed during the ingestion. Hence, in order for the mushroom to survive and thrive it must possess a remarkably aggressive, proactive and protective immune system. – excerpt from Robert Rogers …not unlike humans…

  5. According to one of the top cancer researchers in the UK, medicinal mushrooms  *increase survival times in research trials with breast, lung and prostate cancer patients,  *can shrink cancer tumours by up to 70 per cent (some extracts even caused cancers to disappear)   *stimulate the immune system, for example increasing macrophage activity or stimulating B- and T-lymphocyte production *reduced blood supply to prostate cancer tumours, and,  *reduced side-effects of radiotherapy and chemotherapy (like nausea and hair loss) http://www.canceractive.com/cancer-active-page-link.aspx?n=1488

  6. The bioactive compounds of mushrooms include polysaccharides, proteins, fats, ash, glycosides, alkaloids, volatile oils, tocopherols, phenolics, flavonoids, carotenoids, folates, ascorbic acid enzymes, and organic acids. The active components in mushrooms responsible for conferring anti-cancer potential are lentinan, krestin, hispolon, lectin, calcaelin, illudin S, psilocybin, Hericium polysaccharide A and B (HPA and HPB), ganoderic acid, schizophyllan, laccase, etc… http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339609/

  7. Immunopotientate • Beta glucans stimulate interferon, interleukins, TNF, NK, B and T lymphocytes, tumor-infiltrating lymphocytes; lymphokine activated killer cells, macrophages, granulocytes in bone marrow and production of platelets in bone marrow.

  8. Nerve Cell Liver Cell Cardiac cell Since the 1980s, beta glucan has been known to support the ability of stem cells to expand and survive.

  9. Mushroom Containing Beta Glucans AgaricusBlazeimurrillhttp://www.ncbi.nlm.nih.gov/pubmed/21129005 (shown to reduce pathogenic cytokines) …pathogenic cytokines are responsible for the inflammation and tissue damage characterized by Rheumatiodarthitis Ganodermalucidem - Reishi Grifolafrondosa – Hen of the Woods, Maitake AgaricusBisporuswww.ncbi.nlm.nih.gov/pubmed/19885842 -extracts from A. bisporus activate BMM(bone Marrow Macrophage)

  10. Hericiumerinaceus • Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericiumerinaceushttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176599/

  11. Trametesversicolor • Turkey Tail: anti-viral, tumorcidal, immunopotentiating • Data from multiple epidemiologic and clinical studies on immune effects of conventional cancer treatment and the clinical benefits of polysaccharide immune therapy suggest that immune function has a role in breast cancer prevention. Immune therapy utilizing the polysaccharide constituents of Trametesversicolor (Tv) as concurrent adjuvant cancer therapy may be warranted as part of a comprehensive cancer treatment and secondary prevention strategy. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845472/

  12. Cordycepssinensis • Worlds most costly medicinal mushroom • Evidence showed that the active principles of C. militaris are beneficial to act as pro-sexual, anti-inflammatory, anti-oxidant/anti-aging, anti-tumour/anti-cancer/anti-leukemic, anti-proliferative, anti-metastatic, immunomodulatory, anti-microbial, anti-bacterial, anti-viral, anti-fungal, anti-protozoal, insecticidal, larvicidal, anti-fibrotic, steroidogenic, hypoglacaemic, hypolipidaemic, anti-angiogenetic, anti-diabetic, anti-HIV, anti-malarial, anti-fatigue, neuroprotective, liver-protective, reno-protective as well as pneumo-protective http://www.sciencedirect.com/science/article/pii/S0367326X10001863

  13. Pleurotusostreatus • isolated a homodimeric 32.4 kDalectin from fresh fruiting bodies of the mushroomPleurotuscitrinopileatus. The lectin exerted potent anti-tumor activity in mice bearing sarcoma 180, and caused approximately 80% inhibition of tumor growth when administered intraperitoneally at 5 mg/kg daily for 20 days. • Naturally produces cholersterol reducing lovostatin (StametsGrowing Gourmet and Medicinal Mushrooms)

  14. Ganodermalucidem - Reishi • Anti-tumor effects of Ganodermalucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models. http://www.ncbi.nlm.nih.gov/pubmed/23468988 • Ganodermalucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer. http://www.ncbi.nlm.nih.gov/pubmed/21888505 • It remains uncertain whether G. lucidum helps prolong long-term cancer survival. However, G. lucidum could be administered as an alternative adjunct to conventional treatment in consideration of its potential of enhancing tumour response and stimulating host immunity. http://www.ncbi.nlm.nih.gov/pubmed/22696372

  15. Grifolafrondosa • Oral administration of soluble β-glucans extracted from Grifolafrondosa induces systemic antitumor immune response and decreases immunosuppression in tumor-bearing mice. http://www.ncbi.nlm.nih.gov/pubmed/23280601 • Administration of a polysaccharide from Grifolafrondosa stimulates immune function of normal mice. http://www.ncbi.nlm.nih.gov/pubmed/15298759

  16. G. frondosa cont. • From Sloan Kettering Cancer Research Center; • Maitake demonstrated antitumor effects (16), enhanced bone marrow colony formation, reduced doxorubicin toxicity (11), and inhibited tumor metastasis in vitro (13). In a study done in mice, oral maitake extract promoted maturation of hematopoietic cells to functionally active myeloid cells and enhanced peripheral blood leukocyte recovery following chemotoxic bone marrow injury (17). A novel polysaccharide, MZF, was shown to induce dendritic cell maturation and enhanced antitumor response (20).Maitake also enhanced interferon activity against bladder cancer cells (18) and alleviated inflammation associated with inflammatory bowel disease (19).In a small non-controlled study, tumor regression or significant improvements in symptoms were observed in half of the subjects using Maitake extract (5). In another study of postmenopausal breast cancer patients, oral administration of maitake extract was shown to have immunomodulatory effects (14).More studies are underway to establish Maitake's anticancer potential.

  17. Enoki • In conclusion, the nanomicelles developed in our study provided a promising delivery system for enhancing the oral bioavailability and selective biodistribution of FVS, a potential anti-tumor agent. http://www.ncbi.nlm.nih.gov/pubmed/23524118 • An antitumor polysaccharide, EA3 isolated from a Japanese edible mushroom, Flammulinavelutipes (CURT. ex FR.) SING. is composed of D-glucose. http://europepmc.org/abstract/MED/6891400/reload=0;jsessionid=uH01sRgLGLESErUiwLjF.6

  18. Thank you Food is Medicine!!!

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