Leukemia

1. http://ny-image2.etsy.com/il_fullxfull.115519174.jpg Leukemia By Mary Chen and Genesis Pimentel

2. Website http://whsleukemia.weebly.com • http://whsleukemia.weebly.com

3. What is leukemia? Abnormal leukemia cells • Cancer of the blood • Begins in bone marrow • If healthy, makes white blood cells, red blood cells, and platelets • In a leukemia patient, unregulated growth of immature “leukemia” cells crowds out normal cells • Enters bloodstream  liver, spleen, lymph nodes • 4 Major types: • Acute Myelogenous Leukemia (AML) • Acute Lymphoblastic Leukemia (ALL) • Chronic Myelogenous Leukemia (CML) • Chronic Lymphocytic Leukemia (CLL). http://upload.wikimedia.org/wikipedia/commons/6/6f/Leukemia_cells.png

4. Types of Leukemia • Acute or chronic = how fast the cancer progresses • Acute immediate effects • Chronic gradual and may not show symptoms for years • Myelogenous or Lymphocytic/lymphoblastic depends on type of white blood cell it affects (lymphocytes or myelocytes) • Acute lymphoblastic leukemia: most common childhood cancer • Chronic lymphocytic leukemia: most common in adults, especially those older than 55; rare in children • Acute myelogenous leukemia: both children and adults • Chronic myelogenous leukemia: mainly in adults http://www.uchicagokidshospital.org/specialties/images/cms/uch1001089-1.jpg

5. Risk Factors http://ocw.tufts.edu/data/graphics/genetics.jpg, http://www.fotosearch.com/bthumb/SUE/SUE105/TOBW0151.jpg , http://www.scientificamerican.com/media/inline/D41DB314-E7F2-99DF-3D6ACEC215A9A006_1.jpg • Genetics • Such as chromosomal abnormalities like down syndrome • Family history • Exposure to Dangerous Chemicals • formaldehyde and benzene • Exposure to High Levels of Radiation • Medical radiation like frequent X-rays • Nuclear fallout • Prior history of chemotherapy • Lifestyle factors • Smoking/drug abuse correlate with higher chances of developing leukemia (especially myelogenous leukemia)

6. Symptoms, Detection, & Diagnosis • Common Symptoms • Detection & Diagnosis • physical exam • Swollen lymph nodes/spleen? • Paleness? • blood tests • bone marrow biopsy http://upload.wikimedia.org/wikipedia/commons/3/3a/Symptoms_of_leukemia.png

7. Treatment There are side effects for certain treatments. Chemotherapy causes temporary hair loss. • Depends on age, overall health, stage of cancer, type of cancer, and consideration of side effects • “remission” not “cure” • Chemotherapy: anti-cancer drugs to kill leukemia cells • Surgery: to remove enlarged spleen/cancerous areas • Radiation: high-dose X-rays to treat cancer cells that may stay after surgery • Bone Marrow Transplants: can rebuild a patient's supply of normal blood cells and boost their immune system • radiation or chemotherapy first to destroy the cells in the patient's bone marrow to make room for the donated cells • Biological Therapy: improve the body's natural defenses against cancer • Clinical Trials: studies to test new medicines and other possible treatments http://www.medicgo.com/wp-content/uploads/2010/08/Leukemia-Symptoms-Treatments1.jpg, http://blog.oregonlive.com/hg_impact/2009/04/Marissa_Huddleston_and_brother_Kellen.jpg

8. 5-Year Survival Rate http://en.wikipedia.org/wiki/File:Leukaemia_world_map_-_Death_-_WHO2004.svg • National Cancer Institute Surveillance Epidemiology and End Results Review 2010 Estimate • 43,050 new cases will be diagnosed in US; 21,840 will die • Overall 5-year relative survival from 17 different geographic areas was 54.1% • Breakdown by race and gender • 54.6% for white males, 54.2% for white females • 46.8% for black males, 46.2% for black females. • In US, estimated middle age of death for leukemia is 74 years

9. Interesting Facts http://www.unitedproject.org/images/ribbon_normal/22-orange.jpg • History • Greeks first recognized the disease in the 5th century • "leukemia" comes from Greek "leukos" + "hemia" = white blood • John Hughes Benett made the first diagnosis in 1845, Edinburgh • The disease • affects more men than women but men have a slightly higher survival rate • chronic is more common among older people while acute is mainly pediatric

10. Famous People With Leukemia • Ed Bradley Marie Curie Mary Travers Bill Walsh http://www.aolcdn.com/channels/0f/01/455371ba-002b2-04ec9-400cb8e1, https://thescienceclassroom.wikispaces.com/file/view/Marie_curie_pic.jpg/66535110/Marie_curie_pic.jpg, http://www.chapelhillmemories.com/uploads/Image/P%20MaryJPG%20Medium%20Web%20view.jpg

11. Works Cited • Davis, Bets. "Leukemia - Symptoms, Types, Causes, Diagnoisis and Treatment Options for Leukemia." WebMD. Healthwise, 26 Nov. 2008. Web. 12 Oct. 2010. <http://www.webmd.com/cancer/tc/leukemia-topic-overview>. • "Facts About Leukemia." Cancer Prevention. 2010. Web. 13 Oct. 2010. <http://www.your-cancer-prevention-guide.com/facts-about-leukemia.html>. • "Famous People With Leukemia." HistoryKing. History King, 2010. Web. 16 Oct. 2010. <http://www.historyking.com/Famous-people/Famous-People-With-Leukemia.html>. • Feist, Patty. "Signs of Childhood Cancer." Pediatric Oncology Resource Center. Association of Cancer Online Resources, July 2005. Web. 12 Oct. 2010. <http://www.acor.org/ped-onc/diseases/SOCC.html>. • Leukemia." MayoClinic. Mayo Foundation for Medical Education and Research, 3 Apr. 2010. Web. 13 Oct. 2010. <http://www.mayoclinic.com/health/leukemia/DS00351>. • "Leukemia Home Page." National Cancer Institute. National Cancer Institute, 2010. Web. 11 Oct. 2010. <http://www.cancer.gov/cancertopics/types/leukemia>. • "Leukemia Risk Factors." Oncology Channel. 04 Dec. 2007. Web. 12 Oct. 2010. <http://www.oncologychannel.com/leukemias/risk-factors.shtml>. • Myrrh, Hector. "Leukemia 101." About.com. The New York Times Company, 8 May 2010. Web. 12 Oct. 2010. <http://leukemia.about.com/od/whatisleukemia/a/leukemia101.htm>.