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Agenda

Agenda. Overview of clinical “pull” What is the overall aim? What are the research challenges?. Ultra-Precise Radiotherapy - Cyberknife. Precise Radiotherapy Target radioresistant regions? hypoxic (oxygen-starved) sections of a tumour. But Hypoxic regions are not static

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Agenda

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  1. Agenda • Overview of clinical “pull” • What is the overall aim? • What are the research challenges?

  2. Ultra-Precise Radiotherapy - Cyberknife • Precise Radiotherapy • Target radioresistant regions? • hypoxic (oxygen-starved) sections of a tumour. • But • Hypoxic regions are not static • Imaging (eg CT) is a snapshot • Also – can we measure cancercell kill? • Implanted sensing … • Ian, David

  3. Real Time Tumour Monitoring Miniaturised sensors pH, T, O2, conductivity Implant sensorssurgically into the tumour microenvironment before radiotherapy Sensor chip around 7mmx500μmx500μm … the size of a grass seed

  4. Sensors and Therapy A group of cancer cells

  5. Sensors and Therapy RT-Resistant (1) and RT-sensitive cells (2) and other stuff (3, 4)

  6. Sensors and Therapy Insert chips

  7. Sensors and Therapy Chips detect and signal RT-resistant zones

  8. Sensors and Therapy Deliver extra RT dose to resistant zones

  9. More “direct” measures than O2? • Caspases • “the executioners of cell death” • Hypoxia Inducible Factor (HIF) • Ian/David (why?) • Mark/Andy (how?)

  10. Target radiotherapy sensor chip powered down Find radio-resistant regions Measure cancer cell kill Sensors and Therapy Implant sensors in vivo

  11. Implications – Personalised Therapy • Improved targetting of radiotherapy • Different scheduling strategy • Improved cure rates for many solid cancers • Potential for implanted, local chemotherapy • Major change to NHS practice • Regulation? Acceptability? Value Systems? • Joyce

  12. Social Sciences JoyceTait Implantable Microsystems for Personalised Anti-Cancer Therapy (IMPACT) Engineering Alan Murray, Anthony Walton, Steve McLaughlin Chemistry Mark Bradley Cancer Medicine Ian Kunkler Veterinary Medicine David Argyle

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