1 / 7

Antibiotika

Penicilliner Cefalosporiner Monobactamer Carbapenemer Glycopeptider Polymycin Sulfonamid Trimetoprim. Nitrofuraner Aminoglycosider Tetracyklin Lincosaminer Oxazolidioner Rifamyciner Kinoloner Steroidantibiotika. Antibiotika. Beta-laktam antibiotika. S. S. N. N. O. O.

rico
Download Presentation

Antibiotika

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Penicilliner Cefalosporiner Monobactamer Carbapenemer Glycopeptider Polymycin Sulfonamid Trimetoprim Nitrofuraner Aminoglycosider Tetracyklin Lincosaminer Oxazolidioner Rifamyciner Kinoloner Steroidantibiotika Antibiotika

  2. Beta-laktam antibiotika S S N N O O Penicilliner Cefalosporiner N N O O Carbapenemer Monobactamer

  3. Tetracycliner Makrolider Sulfonamider Trimethoprim Chloramfenikol Bakteriostatisk eller baktericid • ß-lactamer • Aminoglycosider • Glycopeptider • Kinoloner • Metronidazol

  4. Antibiotika angrebspunkt Folinsyresyntesen rammes på to niveauer af Sulfonamider Og trimetoprim DNA replikationen rammes af kinoloner som Ciprofloxacin DNA Mellemprodukter folinsyresyntese ribosomer Proteinsyntesen rammes af makrolider som Erythromycin og af aminoglycosider som gentamycin Cellevægssyntesen rammes af betalactamer som Penicilliner og Cefalosporiner samt af glycopeptidet vancomycin cellevæg

  5. Resistensmekanismer 1) Ændring af angrebspunktet Enzymatisk nedbrydning (beta-laktamaser) Ændret penetration via membranporer Aktiv udpumpning (effluxpumper) Ændrede stofskifteveje

  6. Valg af antibiotika • Empirisk i henhold til klinikken. • Resistensbestemmelse in vitro • Resistensudvikling • Farmakokinetiske forhold • Pris • Håndteringsvenlighed og compliance • Økologiske konsekvenser (giftighed)

  7. Antibiotika kombinationer • Ofte anvendes 3-stof behandling • Blandingsinfektioner • Ukendt ætiologi • Ønske om forstærket virkning (synergisme) • Målrettes ofte efterfølgende iht. udredning. • OBS! indifferente og antagonistiske kombinationer

More Related