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Gastric Cancer in the World

Authors: Turma 14 Supervisors: Mário Dinis Ribeiro Cláudia Camila Dias Professor Doutor Altamiro da Costa Pereira FMUP/SBIM. Assessment of Quality Of Life in patients treated with Chemo and Radiotherapy for Gastric Cancer: A Systematic Review. Gastric Cancer in the World. 35. 31. 30. 25.

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Gastric Cancer in the World

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  1. Authors: Turma 14Supervisors: Mário Dinis RibeiroCláudia Camila Dias Professor Doutor Altamiro da Costa PereiraFMUP/SBIM Assessment of Quality Of Life in patients treated with Chemo and Radiotherapy for Gastric Cancer: A Systematic Review

  2. Gastric Cancer in the World 35 31 30 25 20 16 14 15 13 10 10 9 10 8 8 8 8 6 4 4 4 5 4 3 3 3 2 1 1 1 0 0 0 0 0 0 NHL Skin CCR Liver Stomach Lung Ovary Uterus Breast Thyroid Prostate Pancreas Leukemia Oesophagus Men Women 850 000 deaths worlwide each year cause due to gastric cancer Eucan - Database World, age-standardized rates (per 100.000 persons.year) FMUP/SBIM

  3. Gastric Cancer in Europe Cumulative risk, 0-64 years Male Female Eucan - Database FMUP/SBIM

  4. Introduction QoL after Chemo/Radiotherapy in Gastric Cancer • Stomach adenocarcinoma is the most common form of gastric cancer (95% of the cases).1 • Stomach cancer is a multifactorial disease: diet, hereditary factors, Helicobacter pylori infection are possible causes. 2-3 1- http://www. vidasaudavel.pt 2- http://cancer.healthcentersonline.com/gastrointestinalsystemcancer/stomachcancer.cfm 3- http://hcd2.bupa.co.uk/fact_sheets/html/stomach_cancer.html FMUP/SBIM

  5. Introduction QoL after Chemo/Radiotherapy in Gastric Cancer • Treatment for gastric cancer often involves surgery, usually a partial or a total gastrectomy (removal of stomach tissue).2 • Chemotherapy and radiotherapy are standard for some stages of stomach cancer.2 2- http://cancer.healthcentersonline.com/gastrointestinalsystemcancer/stomachcancer.cfm FMUP/SBIM

  6. Introduction QoL after Chemo/Radiotherapy in Gastric Cancer • Chemotherapy is the use of chemical agents to stop cancer cells from growing. • Chemotherapy is considered a systemic treatment.2 • More than half of all people diagnosed with cancer receive chemotherapy.2 2- http://cancer.healthcentersonline.com/gastrointestinalsystemcancer/stomachcancer.cfm FMUP/SBIM

  7. QoL after Chemo/Radiotherapy in Gastric Cancer • Radiotherapy uses high energy x-rays to destroy cancer cells.4 • A small dose of radiotherapy may be very helpful to relieve pain.4 4- http://info.cancerresearchuk.org/cancerstats/types/stomach/?a=5441 FMUP/SBIM

  8. QoL after Chemo/Radiotherapy in Gastric Cancer • These multiple treatments have different consequences in de Quality of Life (QoL) in patients. • QoL cannot be yet universally defined5, however there are many attempts to do so. • Schipper et al. proposed: “the functional effect of illness and its consequent therapy upon a patient, as perceived by the patient”.6 5- Spilker B, ed. Quality of Life and pharmacoeconomics in clinical trials. Philadelphia:Lippincott-Raven, 1996 6- Schipper H, Clinch J, Olweny LM. Definitions and conceptual issues. In: Spilker B, ed. Quality of Life and pharmacoeconomics in clinical trials, Philadephia : Lippincott- Raven, 1996: 11-24 FMUP/SBIM

  9. Aim QoL after Chemo/Radiotherapy in Gastric Cancer ____________________________________________ • To review which instruments were used to measure the QoL in patients with gastric cancer submitted to chemo and radiotherapy. • To summarize QoL measures across studies. ____________________________________________ FMUP/SBIM

  10. Methods: QoL after Chemo/Radiotherapy in Gastric Cancer • The MesH terms that we use were: ◊ ″Quality of Life And stomach Neoplasms Not surgery. “ Literature searches were conducted in Medline. FMUP/SBIM

  11. Limits: Publication Date till September 2005. Only items with an abstract. Humans.

  12. Methods • Inclusion Criteria • Articles in which QoL was evaluated in patients with gastric cancer and were treated by chemo and radiotherapy. FMUP/SBIM

  13. Methods QoL after Chemo/Radiotherapy in Gastric Cancer • After searching in Medline 45 articles were found. Due to the applying of the inclusion and exclusion criteria the number of articles was reduced to 13. FMUP/SBIM

  14. Fluxogram QoL after Chemo/Radiotherapy in Gastric Cancer

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